Parkin J E, Button K L, Maroudas P A
School of Pharmacy, Curtin University of Technology, Western Australia.
J Clin Pharm Ther. 1992 Jun;17(3):191-6. doi: 10.1111/j.1365-2710.1992.tb01292.x.
High-performance liquid chromatographic (HPLC) assays have been developed for phenylmercuric nitrate and mercuric ions in the presence of disodium edetate. Application of these methods to neomycin eye drops of the Pharmaceutical Codex and Australian Pharmaceutical Formulary, which contain both phenylmercuric nitrate and disodium edetate, show that edetate promotes approximately 20% decomposition of the phenylmercuric nitrate in the drops of the Pharmaceutical Codex but little in the drops of the Australian Pharmaceutical Formulary during sterilization by the recommended method. The reason for the stability of the organomercurial in the Australian product was determined as being due to the presence of sodium chloride in the formulation.
已开发出高效液相色谱（HPLC）分析法，用于在乙二胺四乙酸二钠存在的情况下测定硝酸苯汞和汞离子。将这些方法应用于《英国药典》和《澳大利亚药物处方集》中的新霉素眼药水，这些眼药水同时含有硝酸苯汞和乙二胺四乙酸二钠，结果表明，按照推荐方法进行灭菌时，乙二胺四乙酸在《英国药典》药水中能促进约20%的硝酸苯汞分解，但在《澳大利亚药物处方集》药水中的促进作用很小。已确定澳大利亚产品中有机汞稳定性的原因是制剂中存在氯化钠。
