Parkin J E
School of Pharmacy, Curtin University of Technology, Perth, Western Australia.
J Pharm Pharmacol. 1993 Dec;45(12):1024-7. doi: 10.1111/j.2042-7158.1993.tb07173.x.
Analytical methods have been developed which enable phenylmercuric nitrate, mercuric ion and diphenylmercury to be measured in sulphacetamide drops. Application of these methods demonstrate that during heat sterilization of both 10 and 30% sulphacetamide drops containing phenylmercuric nitrate, together with disodium edetate and sodium metabisulphite, there is a 20-30% overall loss of phenylmercuric nitrate. This loss occurs mainly due to the phenylmercuric ion establishing an equilibrium with equimolar amounts of mercuric ion and diphenylmercury.
已经开发出了一些分析方法，这些方法能够测定磺胺醋酰滴眼剂中的硝酸苯汞、汞离子和二苯汞。这些方法的应用表明，在含有硝酸苯汞、乙二胺四乙酸二钠和焦亚硫酸钠的10%和30%磺胺醋酰滴眼剂进行热灭菌时，硝酸苯汞的总损失率为20%至30%。这种损失主要是由于苯汞离子与等摩尔量的汞离子和二苯汞建立了平衡。
