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高效液相色谱法研究滴眼剂配方中硝酸苯汞与焦亚硫酸钠的相互作用

High-performance liquid chromatographic investigation of the interaction of phenylmercuric nitrate and sodium metabisulphite in eye drop formulations.

作者信息

Parkin J E

机构信息

School of Pharmacy, Curtin University of Technology, Bentley, Western Australia.

出版信息

J Chromatogr. 1990 Jul 6;511:233-42. doi: 10.1016/s0021-9673(01)93287-x.

DOI:10.1016/s0021-9673(01)93287-x
PMID:2211913
Abstract

The degradation of phenylmercuric nitrate in the presence of sodium metabisulphite in eye drop formulations has been investigated using a stability-indicating high-performance liquid chromatographic (HPLC) method. HPLC methods have been developed for the quantitation of the principal degradation products (diphenyl-mercury, benzenesulphonic acid and benzenesulphinic acid) and a mechanism is proposed for their formation. The pharmaceutical significance of the interaction is briefly discussed.

摘要

采用稳定性指示高效液相色谱（HPLC）法，研究了滴眼液制剂中偏亚硫酸氢钠存在下硝酸苯汞的降解情况。已开发出HPLC方法用于定量主要降解产物（二苯基汞、苯磺酸和苯亚磺酸），并提出了其形成机制。简要讨论了该相互作用的药学意义。

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