颈动脉体瘤外科治疗的当前概念。

Current concepts for the surgical management of carotid body tumor.

作者信息

Knight Theron T, Gonzalez Jose Andres, Rary John M, Rush Daniel S

机构信息

Department of Surgery, James H. Quillen College of Medicine, East Tennessee State University, P. O. Box 70575, Johnson City, TN 37614, USA.

出版信息

Am J Surg. 2006 Jan;191(1):104-10. doi: 10.1016/j.amjsurg.2005.10.010.

DOI:10.1016/j.amjsurg.2005.10.010

PMID:16399116

Abstract

BACKGROUND

Carotid body tumor (CBT) is a rare lesion of the neuroendocrine system. Chronic hypoxia has long been recognized as an etiology of CBT and other paragangliomas. Recent biogenetic discoveries reveal that mutations in oxygen-sensing genes are another etiology, accounting for approximately 35% of cases, and that these 2 etiologies are probably additive.

DATA SOURCES

(1) A retrospective analysis of fifteen cases of CBT in a 6-year period occurring in the mountains of Southern Appalachia; (2) an extensive review of the literature on the surgery of CBT and on the expansive biogenetic understanding of the disease.

CONCLUSIONS

Improved imaging, vascular surgical techniques, and understanding of the disease have vastly improved outcomes for patients. The necessities for long-term follow-up and appropriate genetic testing and counseling of patients and their families are documented. Surgeon and institutional competence are critical in achieving maximal outcomes.

摘要