Sajid M S, Hamilton G, Baker D M
Vascular Unit, Department of Surgery, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, UK.
Eur J Vasc Endovasc Surg. 2007 Aug;34(2):127-30. doi: 10.1016/j.ejvs.2007.01.015. Epub 2007 Apr 2.
Carotid body tumour (CBT) is a rare but the most common form of head and neck paraganglioma (PGL). We present the biggest ever series on CBT in UK/EU discussing diagnostic challenges, surgical treatment and complications of surgical intervention.
A detailed proforma was designed and sent to all members of Joint Vascular Research Group (JVRG). Data of 95 patients was collected. Generic terms including carotid body tumour/s, or paraganglioma/s were used to search a variety of electronic database in order to get latest informations available in literature.
A total of 95 patients were recorded in our data from 1979 to 2005. Mean age of presentation was 55 years. Incidence was higher in females. CBT was more common on right side (58%). 18% tumours were bilateral. Neck lump (98%) and pressure symptoms including cranial nerve deficits and pain were main presenting complaints. About 18% of tumours were familial. Only 4.2% were malignant. Duplex scan is the best investigation for diagnosis, though MRI, DSA and CT scan are important for preoperative assessment. Surgery is the treatment of choice. Stroke and cranial nerve injury constitute postoperative morbidity (35%) and mortality (1%). Incidence of postoperative cranial nerve deficit was about 19%. Combined ipsilateral and contralateral recurrence rate was 4.2%.
CBT is a rare condition which needs surgical excision by experienced vascular surgeon. Surgical resection is associated with significant morbidity of 35% and mortality of 1%. Mostly CBT is benign but malignant forms are not uncommon.
颈动脉体瘤（CBT）是一种罕见但却是头颈部副神经节瘤（PGL）最常见的形式。我们呈现了英国/欧盟有史以来关于CBT的最大系列研究，讨论诊断挑战、手术治疗及手术干预的并发症。
设计了一份详细的表格并发送给联合血管研究组（JVRG）的所有成员。收集了95例患者的数据。使用包括颈动脉体瘤或副神经节瘤等通用术语搜索各种电子数据库，以获取文献中最新的信息。
我们的数据记录了1979年至2005年期间的95例患者。出现症状时的平均年龄为55岁。女性发病率更高。CBT在右侧更常见（58%）。18%的肿瘤为双侧性。颈部肿块（98%）以及包括颅神经缺损和疼痛在内的压迫症状是主要的就诊主诉。约18%的肿瘤为家族性。仅4.2%为恶性。双功扫描是诊断的最佳检查方法，尽管MRI、DSA和CT扫描对术前评估也很重要。手术是首选治疗方法。中风和颅神经损伤构成术后发病率（35%）和死亡率（1%）。术后颅神经缺损的发生率约为19%。同侧和对侧联合复发率为4.2%。
CBT是一种罕见疾病，需要由经验丰富的血管外科医生进行手术切除。手术切除伴有35%的显著发病率和1%的死亡率。大多数CBT是良性的，但恶性形式也并不罕见。
