一种接触性皮炎的新动物模型：无毛豚鼠。

A new animal model for contact dermatitis: the hairless guinea pig.

作者信息

Miyauchi H, Horio T

机构信息

Department of Dermatology, Kansai Medical University, Osaka, Japan.

出版信息

J Dermatol. 1992 Mar;19(3):140-5. doi: 10.1111/j.1346-8138.1992.tb03197.x.

DOI:10.1111/j.1346-8138.1992.tb03197.x

PMID:1640019

Abstract

Allergic and irritant contact reactions were evaluated in the recently identified hairless guinea pig, Crl:IAF(HA)BR, a mutant from the Hartley strain. The cutaneous changes were observed macro- and microscopically. The irritant contact dermatitis was induced by croton oil, 2,4-dinitrochlorobenzene (DNCB), or anthralin. Both hairless and hairy guinea pigs developed similar reactions to these chemicals. The density of the epidermal Langerhans cells (LC) of hairless guinea pigs was significantly higher than that in the hairy strain. Allergic contact sensitization was easily induced with DNCB. Photoallergic contact sensitization was also induced with tetrachlorosalicylanilide (TCSA) but not with tribromosalicylanilide (TBS). However, by administration of cyclophosphamide before sensitization, positive photocontact responses were seen with TBS. These results indicate that hairless guinea pigs can be used as animal models for investigation of immunologic and nonimmunologic contact reactions.

摘要

在最近鉴定出的无毛豚鼠Crl:IAF(HA)BR（一种来自Hartley品系的突变体）中评估了变应性和刺激性接触反应。通过宏观和微观观察皮肤变化。巴豆油、2,4-二硝基氯苯（DNCB）或蒽林可诱发刺激性接触性皮炎。无毛和有毛豚鼠对这些化学物质产生相似的反应。无毛豚鼠表皮朗格汉斯细胞（LC）的密度显著高于有毛品系。用DNCB很容易诱导变应性接触致敏。用四氯水杨酰苯胺（TCSA）也可诱导光变应性接触致敏，但用三溴水杨酰苯胺（TBS）则不能。然而，在致敏前给予环磷酰胺，TBS可产生阳性光接触反应。这些结果表明，无毛豚鼠可作为研究免疫性和非免疫性接触反应的动物模型。