青蒿琥酯对豚鼠变应性接触性皮炎的局部应用

Topical application of artesunate on guinea pig allergic contact dermatitis.

作者信息

Chen H, Maibach H I

机构信息

Department of Dermatology, University of California, School of Medicine.

出版信息

Contact Dermatitis. 1994 May;30(5):280-2. doi: 10.1111/j.1600-0536.1994.tb00598.x.

DOI:10.1111/j.1600-0536.1994.tb00598.x

PMID:8088141

Abstract

Artesunate is derived from the Chinese medicinal herb qinghao. Many animal studies suggest that systemic artesunate has immunoregulatory activity. We investigated the effect of topical artesunate on contact sensitivity in guinea pigs sensitized with DNCB. Female hairless guinea pigs were used and the contact reaction graded by visual (5 point) score and erythema measured with a color analyzer. Topical artesunate inhibited the elicitation reaction of contact hypersensitivity when given at the 1st and 12th h after challenge (p < 0.05), but showed no effect when given from day 3 to day 1 before challenge (p > 0.05). Artesunate had no effect on toxic (irritant) contact dermatitis from 20% croton oil (p > 0.05). The results indicate that topical application of artesunate may offer a novel treatment of allergic contact dermatitis and other cutaneous immune-mediated disorders.

摘要

青蒿琥酯源自中药材青蒿。许多动物研究表明，全身性青蒿琥酯具有免疫调节活性。我们研究了局部应用青蒿琥酯对用二硝基氯苯致敏的豚鼠接触敏感性的影响。使用雌性无毛豚鼠，通过视觉（5分）评分对接触反应进行分级，并用颜色分析仪测量红斑。在激发后第1小时和第12小时给予局部青蒿琥酯可抑制接触性超敏反应的激发反应（p<0.05），但在激发前第3天至第1天给予时则无作用（p>0.05）。青蒿琥酯对20%巴豆油引起的毒性（刺激性）接触性皮炎无作用（p>0.05）。结果表明，局部应用青蒿琥酯可能为过敏性接触性皮炎和其他皮肤免疫介导的疾病提供一种新的治疗方法。