Horio T
J Invest Dermatol. 1976 Nov;67(5):591-3. doi: 10.1111/1523-1747.ep12541692.
Allergic photocontact sensitization could be induced in guinea pigs with 3,3',4',5-tetrachlorosalicylanilide (TCSA), 3,4',5-tribromosalicylanilide (TBS), and bithionol using pretreatment with sodium lauryl sulfate (SLS) and long-wave ultraviolet (UVA) radiation. Mid-wave ultraviolet below 320 nm (UVB) was not necessary for the induction of sensitization. Combined use of SLS pretreatment with UVA radiation resulted in more effective sensitization than combined UVB and UVA radiation. Higher sensitization rates to TCSA and TBS were achieved by allowing rest periods between each of 5 2-hr exposures to UVA than by daily 1-hr exposures for 10 consecutive days. The opposite result was obtained with bithionol. Although UVB has been customarily used in the past for induction of photosensitivity, its role is only to irritate the site of induction.
使用月桂醇硫酸酯钠（SLS）预处理和长波紫外线（UVA）辐射，可在豚鼠中诱导出对3,3',4',5-四氯水杨酰苯胺（TCSA）、3,4',5-三溴水杨酰苯胺（TBS）和硫双二氯酚的过敏性光接触致敏。低于320 nm的中波紫外线（UVB）对于致敏诱导并非必需。SLS预处理与UVA辐射联合使用比UVB和UVA辐射联合使用导致更有效的致敏。通过在每次2小时的UVA暴露之间留出休息时间，比连续10天每天1小时暴露，对TCSA和TBS实现了更高的致敏率。硫双二氯酚得到了相反的结果。尽管过去通常使用UVB来诱导光敏性，但其作用仅在于刺激诱导部位。
