Wang Ping-zhong, Yu Qiang, Shi Hui-min, Luo Ji-cheng
Department of Radiology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China.
Shanghai Kou Qiang Yi Xue. 2005 Dec;14(6):573-7.
The aim of this study was to determine whether CT perfusion was valuable in differentiating benign tumors from malignant ones in the parotid gland.
Fifty-three parotid gland tumors, 35 benign and 18 malignant, in 51 patients were included in this study. All the tumors were confirmed histopathologically and examined with CT perfusion before operations. The parameters of CT perfusion, including blood flow (BF: ml x 100g(-1) x min(-1)), blood volume (BV: ml x 100g(-1)), mean transmit time (MTT:s) and permeability surface (PS: ml x 100g(-1) x min(-1)) were evaluated. Wilcoxon sign sum test, a nonparameters test for paired data were used to determine the statistical differences of parameters between the benign and malignant tumors.
The mean values +/- standard variations of BF, BV, MTT and PS were 139.85+/-175.13, 17.16+/-15.67, 13.27+/-4.42, and 24.38+/-14.52 respectively in benign tumors, versus 231.69+/-205.29, 32.22+/-20.56, 11.40+/-3.95 and 38.28+/-19.00 respectively in malignant tumors. Except for MTT, the differences of BF, BV and PS between benign and malignant tumors were statistically significant (P<0.01).
On the basis of the results of this study, the parameters of CT perfusion, BF, BV and PS, were valuable in differentiating benign and malignant tumors of the parotid gland.
本研究旨在确定CT灌注成像在鉴别腮腺良性肿瘤与恶性肿瘤方面是否具有价值。
本研究纳入了51例患者的53个腮腺肿瘤，其中35个为良性，18个为恶性。所有肿瘤均经组织病理学证实，并在手术前行CT灌注检查。评估CT灌注参数，包括血流量（BF：ml×100g⁻¹×min⁻¹）、血容量（BV：ml×100g⁻¹）、平均通过时间（MTT：s）和表面通透性（PS：ml×100g⁻¹×min⁻¹）。采用配对数据的非参数检验Wilcoxon符号秩和检验来确定良性和恶性肿瘤之间参数的统计学差异。
良性肿瘤的BF、BV、MTT和PS的平均值±标准差分别为139.85±175.13、17.16±15.67、13.27±4.42和24.38±14.52，而恶性肿瘤的相应值分别为231.69±205.29、32.22±20.56、11.40±3.95和38.28±19.00。除MTT外，良性和恶性肿瘤之间的BF、BV和PS差异具有统计学意义（P<0.01）。
基于本研究结果，CT灌注参数BF、BV和PS在鉴别腮腺良恶性肿瘤方面具有价值。
