Takeda Toshinobu, Koyama Tomonori, Kanai Chieko, Kurita Hiroshi
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Psychiatry Clin Neurosci. 2005 Dec;59(6):717-22. doi: 10.1111/j.1440-1819.2005.01442.x.
This study attempted to find clinical variables evaluated at age 2 that would predict mental retardation (MR, IQ/cognition-adaptation developmental quotient [C-A DQ]<70) at age 5 in 57 children with pervasive developmental disorder (PDD). About two-thirds of subjects had MR at both initial and outcome evaluations. The C-A DQ at initial evaluation was significantly lower in mentally retarded PDD (MRPDD) than in high-functioning (IQ >or= 70) PDD (HFPDD). MRPDD changed less than HFPDD in IQ/C-A DQ between ages 2 and 5. The C-A DQ at age 2 was a potent predictor for MR at age 5 and the total score and three item scores of Childhood Autism Rating Scale-Tokyo Version evaluated at age 2 were also useful in predicting MR at age 5.
本研究试图找出在2岁时评估的临床变量，这些变量能够预测57名广泛性发育障碍（PDD）儿童在5岁时的智力迟钝（MR，智商/认知-适应发育商数[C-A DQ]<70）情况。约三分之二的受试者在初始评估和最终评估时均存在智力迟钝。在初始评估中，智力迟钝的PDD（MRPDD）儿童的C-A DQ显著低于高功能（智商≥70）的PDD（HFPDD）儿童。MRPDD儿童在2岁至5岁之间智商/C-A DQ的变化小于HFPDD儿童。2岁时的C-A DQ是5岁时智力迟钝的有力预测指标，2岁时评估的儿童自闭症评定量表-东京版的总分及三个项目得分在预测5岁时的智力迟钝方面也很有用。
