Loizzo M R, Tundis R, Statti G A, Miljkovic-Brake Ana, Menichini F, Houghton P J
Department of Pharmaceutical Sciences, University of Calabria, I-87036 Arcavacata di Rende, CS, Italy.
Nat Prod Res. 2006 Mar;20(3):265-9. doi: 10.1080/14786410500077823.
The antimicrobial and cytotoxic activities of extracts from Senecio samnitum Huet are reported. Extracts from S. samnitum were able to inhibit the in vitro proliferation of four human tumor cell lines. The dichloromethane extract demonstrated effective cytotoxic activity with IC50 of 22.89 microg mL(-1) on the Caco-2 cell line and the EtOAc extract had IC50 value of 11.91 microg mL(-1) against the COR-L23 cell line. The n-hexane extract displayed the best antibacterial activity against Gram positive bacteria, particularly Staphylococcus aureus. The antifungal activity of all extracts was also seen, particularly against the dermatophytes Trichophyton tonsurans and Microsporum gypseum for the methanol and n-hexane extracts.
报道了千里光提取物的抗菌和细胞毒性活性。千里光提取物能够抑制四种人类肿瘤细胞系的体外增殖。二氯甲烷提取物对Caco-2细胞系表现出有效的细胞毒性活性，IC50为22.89微克/毫升，乙酸乙酯提取物对COR-L23细胞系的IC50值为11.91微克/毫升。正己烷提取物对革兰氏阳性菌，尤其是金黄色葡萄球菌表现出最佳的抗菌活性。所有提取物也都表现出抗真菌活性，尤其是甲醇和正己烷提取物对须癣毛癣菌和石膏样小孢子菌的抗真菌活性。
