Tundis R, Loizzo M R, Statti G A, Houghton P J, Miljkovic-Brake A, Menichini F
Department of Pharmaceutical Sciences, University of Calabria, Rende (CS), Italy.
Nat Prod Res. 2007 May;21(5):396-400. doi: 10.1080/14786410500520111.
This study reports on the alpha-amylase inhibitory and antimicrobial activities of Senecio leucanthemifolius Poiret. Extracts of S. leucanthemifolius were tested for their antimicrobial and antifungal activities against seven different pathogenic microorganisms using the microdilution technique. The ethyl acetate extract exhibited a strong antibiotic activity against Staphylococcus aureus with a MIC value of 31.25 microg mL(-1), while the n-hexane extract showed a significant activity against dermatophytic fungi. S. leucanthemifolius extracts were tested also for their potential hypoglycemic activity through the in vitro inhibition of alpha-amylase. The dichloromethane extract inhibited alpha-amylase with a value of 56.6% at 0.05 mg mL(-1) and the n-butanol extract showed a value of 89.2% at 1 mg mL(-1).
本研究报道了白背千里光（Senecio leucanthemifolius Poiret）的α-淀粉酶抑制活性和抗菌活性。采用微量稀释技术，对白背千里光提取物针对七种不同致病微生物的抗菌和抗真菌活性进行了测试。乙酸乙酯提取物对金黄色葡萄球菌表现出较强的抗菌活性，最低抑菌浓度（MIC）值为31.25微克/毫升，而正己烷提取物对皮肤癣菌显示出显著活性。还通过体外抑制α-淀粉酶测试了白背千里光提取物的潜在降血糖活性。二氯甲烷提取物在0.05毫克/毫升时对α-淀粉酶的抑制率为56.6%，正丁醇提取物在1毫克/毫升时的抑制率为89.2%。
