Dallongeville Jean, Grupposo Marie-Catherine, Cottel Dominique, Ferrières Jean, Arveiler Dominique, Bingham Annie, Ruidavets Jean-Bernard, Haas Bernadette, Ducimetière Pierre, Amouyel Philippe
INSERM U508, Institut Pasteur de Lille, 1 rue du Pr Calmette, 59019 Lille Cedex, France.
Eur Heart J. 2006 Mar;27(6):722-8. doi: 10.1093/eurheartj/ehi717. Epub 2006 Jan 9.
The goal of this study is to assess the association between the metabolic syndrome (MS) and parental history of cardiovascular disease (CVD).
Participants were recruited in a population survey of 3441 men and women, aged 35-64. MS was defined with NCEP-III guidelines. Familial history of myocardial infarction (MI), angina, and stroke was assessed with a standardized questionnaire. Parental premature CVD was defined if CVD occurred before 55/65 years in the father/mother. A total of 390 men and 281 women had MS. Positive parental CVD was associated with MS in women (43.0 vs. 36.8%, P<0.001) but not in men (36.9 vs. 31.8%, P=0.06). Similarly, parental premature CVD was associated with MS in women (19.2 vs. 11.8%, P<0.0007) but not in men (11.1 vs. 11.1%, ns). In women with MS, the age, centre, and educational level adjusted odds ratios [OR (95% CI)] of having a positive parental premature stroke was 1.84 (1.0-3.38), P=0.049. This OR was 1.76 (1.23-2.76), P=0.007 for combined parental premature MI and stroke and 1.67 (1.17-2.38), P=0.004 for combined premature MI, stroke, and angina. After further adjustment on personal coronary heart disease and CVD risk factors, the ORs of having a positive parental history of combined premature MI and stroke [1.75 (1.11-2.76), P=0.016] or MI, stroke, and angina [1.79 (1.21-2.63), P=0.003], remained statistically significant, in women with MS.
The MS is associated with parental premature CVD independently of classical CV risk factors, suggesting that MS is a contributor to the familial aggregation of premature CVD.
本研究旨在评估代谢综合征（MS）与心血管疾病（CVD）家族史之间的关联。
在一项针对3441名年龄在35 - 64岁的男性和女性的人群调查中招募参与者。MS根据美国国家胆固醇教育计划成人治疗组第三次报告（NCEP - III）指南进行定义。通过标准化问卷评估心肌梗死（MI）、心绞痛和中风的家族史。如果父亲/母亲在55/65岁之前发生CVD，则定义为父母过早发生CVD。共有390名男性和281名女性患有MS。母亲患有CVD与女性患MS相关（43.0%对36.8%，P<0.001），但与男性无关（36.9%对31.8%，P = 0.06）。同样，母亲过早发生CVD与女性患MS相关（19.2%对11.8%，P<0.0007），但与男性无关（11.1%对11.1%，无显著性差异）。在患有MS的女性中，经年龄、中心和教育水平调整后的母亲过早发生中风呈阳性的比值比[OR（95%置信区间）]为1.84（1.0 - 3.38），P = 0.049。母亲过早发生MI和中风合并呈阳性时，该OR为1.76（1.23 - 2.76），P = 0.007；母亲过早发生MI、中风和心绞痛合并呈阳性时，该OR为1.67（1.17 - 2.38），P = 0.004。在对个人冠心病和CVD危险因素进行进一步调整后，患有MS的女性中，母亲过早发生MI和中风合并呈阳性[1.75（1. ... 2.76），P = 0.016]或MI、中风和心绞痛合并呈阳性[1.79（1.21 - 2.63），P = 0.003]的OR仍具有统计学意义。
MS与父母过早发生CVD相关，且独立于经典的心血管危险因素，这表明MS是过早发生CVD家族聚集性的一个促成因素。
