Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Int J Cardiol. 2009 May 29;134(3):313-21. doi: 10.1016/j.ijcard.2008.12.025. Epub 2009 Jan 8.
The purpose of this study was to investigate whether the presence of the NCEP-ATP III defined metabolic syndrome (MS) is associated with the future development of cardiovascular disease (CVD) and diabetes in Koreans.
The study subjects were recruited from among those who visited the Health Promotion Center at the Samsung Medical Center. 2435 subjects (1761 men and 674 women), 20 to 78 years of age, were enrolled and evaluated for the development of new onset CVD (coronary heart disease [CHD] and stroke) during a mean 8.7 years of follow-up.
The prevalence of the MS at baseline was 21.7% (382/1761) and 11.4% (77/674) in men and women respectively, and the MS was found to be associated with the risk for CVD in both men and women (OR, 1.98; 95% CI, 1.30-3.03 in men, 4.04; 95% CI, 1.78-9.14 in women). More specifically, the MS was associated with the risk for future CHD (OR, 3.68; 95% CI, 1.93-7.01) in men and stroke (OR, 3.96; 95% CI, 1.58-9.94) in women. However, no statistical differences were found between the HOMA-IR tertiles with regard to the risk for CVD. After controlling for fasting plasma glucose (FPG) levels, the predictive power of the MS for an increased risk for diabetes was dramatically decreased (OR, from 3.69 to 1.77) in men, and it no longer was a predictor in women.
The NCEP-defined MS was found to be associated with the risk for future CVD, i.e., CHD in men and stroke in women.
本研究旨在探讨 NCEP-ATP III 定义的代谢综合征（MS）是否与韩国人未来发生心血管疾病（CVD）和糖尿病有关。
研究对象从三星医疗中心健康促进中心就诊者中招募。共纳入 2435 名 20-78 岁受试者，随访 8.7 年，评估新发 CVD（冠心病[CHD]和卒中）的发生情况。
基线时 MS 的患病率在男性和女性中分别为 21.7%（382/1761）和 11.4%（77/674），MS 与男性和女性 CVD 风险均相关（OR，1.98；95%CI，1.30-3.03；OR，4.04；95%CI，1.78-9.14）。更具体地说，MS 与男性未来 CHD（OR，3.68；95%CI，1.93-7.01）和女性卒中（OR，3.96；95%CI，1.58-9.94）风险相关。然而，HOMA-IR 三分位组之间 CVD 风险无统计学差异。校正空腹血糖（FPG）水平后，MS 对男性发生糖尿病风险的预测能力显著下降（OR 从 3.69 降至 1.77），而女性则不再是预测因素。
NCEP 定义的 MS 与未来 CVD 风险相关，即男性发生 CHD，女性发生卒中。
