Kasaj Adrian, Willershausen Brita, Berakdar Mohamad, Tekyatan Haki, Sculean Anton
Department of Operative Dentistry, Johannes Gutenberg University, Mainz, Germany.
Clin Oral Investig. 2006 Mar;10(1):72-6. doi: 10.1007/s00784-005-0029-9. Epub 2006 Jan 10.
The purpose of the present study was to evaluate clinically the effect of an oily calcium hydroxide suspension on early wound healing after nonsurgical periodontal therapy. A total of 19 patients with chronic periodontitis were enrolled in the study. Each subject had three sites in each of two contra-lateral jaw quadrants with a probing pocket depth (PPD) of > or =5 mm and bleeding on probing (BoP+). All teeth received scaling and root planing under local anesthesia followed by irrigation with sterile saline. An oily calcium hydroxide suspension (Osteoinductal) was applied subgingivally to the test sites at random. All sites were reexamined after 1, 2 [gingival index (GI) and BoP], and 3 weeks (GI, BoP, and PPD). Treatment success was defined as no signs of GI (GI=0), no BoP (BoP-), and pocket closure (PPD< or =4 mm). At all three different points in time, there were improvements in both GI and BoP at the control and test sites, which were in favor of the test therapy (p<0.05). For PPD change, no differences were found between the test and the control sites. The results of the study suggest that the topical application of an oily calcium hydroxide suspension (Osteoinductal), after nonsurgical periodontal therapy, improves early periodontal wound healing.
本研究的目的是临床评估油性氢氧化钙悬浊液对非手术牙周治疗后早期伤口愈合的影响。共有19例慢性牙周炎患者纳入本研究。每个受试者在两个对侧颌面部象限各有三个位点，探诊袋深度（PPD）≥5mm且探诊出血（BoP+）。所有牙齿在局部麻醉下进行龈下刮治和根面平整，随后用无菌生理盐水冲洗。将油性氢氧化钙悬浊液（Osteoinductal）随机龈下应用于试验位点。在1周、2周（牙龈指数（GI）和BoP）和3周（GI、BoP和PPD）后对所有位点进行复查。治疗成功定义为无GI体征（GI=0）、无BoP（BoP-）且袋深闭合（PPD≤4mm）。在所有三个不同时间点，对照位点和试验位点的GI和BoP均有改善，这有利于试验治疗（p<0.05）。对于PPD变化，试验位点和对照位点之间未发现差异。研究结果表明，在非手术牙周治疗后局部应用油性氢氧化钙悬浊液（Osteoinductal）可改善早期牙周伤口愈合。
