Kohal R J, Hürzeler M B, Schneider S R, Riede U N, Caffesse R G
Department of Prosthodontics, Albert-Ludwigs-University, Freiburg, Germany.
Clin Oral Implants Res. 1997 Oct;8(5):375-85. doi: 10.1034/j.1600-0501.1997.080504.x.
The aim of this investigation was to evaluate the effect of a new calcium hydroxide suspension (Osteoinductal) on the healing process of endosseous dental implants after placement. The material, composed of 25% calcium hydroxide, 25% Oleum pedum tauri and 50% vaselinum album, was developed with the intention to accelerate and to increase the mineralized bone to implant contact during the healing phase. Eight adult beagle dogs were used in this study. Prior to the beginning of the study the dogs had all mandibular premolars extracted. After the extraction sites had healed for 3 months, implant osteotomies were performed. On one side of the mandibular premolars extracted. After the extraction sites had healed for 3 months, implant osteotomies were performed. On one side of the mandible Osteoinductal was applied into the osteotomies before placement of the implants, whereas the other side did not receive Osteoinductal. A total of 48 implants were placed with two losses during the entire study period. Two dogs were sacrificed 1 week, 2 weeks, 4 weeks and 3 months after implant placement. The specimens were evaluated histologically and histomorphometrically. In the histological evaluation an intense inflammatory reaction towards the calcium hydroxide suspension was found leading to a destruction of the bone surrounding the implants after 1 and 2 weeks. A giant cell reaction against the test material was visible at 4 weeks. At 3 months no inflammatory and no giant cell reaction could be depicted in the test group. The mean direct bone to implant contact or inflammatory tissue to implant contact showed no differences between test and control group for 1 and 2 weeks. Although statistically not significant, there was a clinical significant difference in the mineralized bone to implant contact between test and control group for the last two timepoints (i.e. 4-week specimens: test group 2.3 +/- 0.9%, control group 26.8 +/- 11.1%; 3-month specimens: test group 10.5 +/- 12.7%, control group 60.7 +/- 13.7%). This study indicates that the use of the calcium hydroxide suspension Osteoinductal has a detrimental effect on wound healing and osseointegration of dental implants and cannot be recommended for use with dental implants.
本研究的目的是评估一种新型氢氧化钙悬浮液（Osteoinductal）对牙种植体植入后愈合过程的影响。该材料由25%的氢氧化钙、25%的牛蹄油和50%的白凡士林组成，其研发目的是在愈合阶段加速并增加矿化骨与种植体的接触。本研究使用了8只成年比格犬。在研究开始前，所有犬的下颌前磨牙均被拔除。拔牙创口愈合3个月后，进行种植体截骨术。在下颌前磨牙拔除侧，拔牙创口愈合3个月后进行种植体截骨术。在植入种植体前，在下颌一侧的截骨术中应用Osteoinductal，而另一侧不使用Osteoinductal。在整个研究期间，共植入48枚种植体，有2枚丢失。在种植体植入后1周、2周、4周和3个月分别处死2只犬。对标本进行组织学和组织形态计量学评估。在组织学评估中，发现对氢氧化钙悬浮液有强烈的炎症反应，导致植入后1周和2周时种植体周围骨组织破坏。在4周时可见对测试材料的巨细胞反应。在3个月时，测试组未发现炎症和巨细胞反应。在1周和2周时，测试组和对照组的平均直接骨与种植体接触或炎症组织与种植体接触无差异。尽管在统计学上不显著，但在最后两个时间点（即4周标本：测试组2.3±0.9%，对照组26.8±11.1%；3个月标本：测试组10.5±12.7%，对照组60.7±13.7%），测试组和对照组在矿化骨与种植体接触方面存在临床显著差异。本研究表明，使用氢氧化钙悬浮液Osteoinductal对牙种植体的伤口愈合和骨结合有不利影响，不建议用于牙种植体。
