So Y T, Beckstead J H, Davis R L
Ann Neurol. 1986 Nov;20(5):566-72. doi: 10.1002/ana.410200503.
Twenty cases of primary lymphoma of the central nervous system associated with acquired immune deficiency syndrome were seen over a period of four years and were studied clinically and pathologically. Biopsy established the diagnosis in 11 cases, and autopsy confirmed it in 9. Multicentricity was demonstrated in all cases for which there was adequate autopsy material. Both large-cell immunoblastic and small noncleaved lymphomas were seen, and marker studies in 5 patients established that the lymphomas were of B-cell origin. Neurological symptoms and signs, cerebrospinal fluid characteristics, and radiographic appearance were reviewed. The clinical and radiographic picture is nonspecific and histological confirmation is essential for diagnosis. Although the tumor appears to be radiosensitive, prognosis is extremely poor, with an average survival of less than two months.
在四年时间里共发现20例与获得性免疫缺陷综合征相关的原发性中枢神经系统淋巴瘤，并对其进行了临床和病理研究。11例经活检确诊，9例经尸检证实。在所有有足够尸检材料的病例中均显示有多中心性。可见大细胞免疫母细胞性淋巴瘤和小无裂细胞性淋巴瘤，5例患者的标记研究证实这些淋巴瘤起源于B细胞。回顾了神经症状和体征、脑脊液特征及影像学表现。临床和影像学表现不具特异性，组织学确诊对诊断至关重要。尽管肿瘤似乎对放疗敏感，但预后极差，平均生存期不到两个月。
