Colson Natalie J, Lea Rod A, Quinlan Sharon, Griffiths Lyn R
Genomics Research Centre, School of Health Science, Griffith University, Gold Coast, Qld 9726, Australia.
Mol Genet Metab. 2006 Jun;88(2):107-13. doi: 10.1016/j.ymgme.2005.11.013. Epub 2006 Jan 5.
Migraine is a primary headache disorder that involves both genetic and environmental components. Migraine is considered to be a polygenic disorder with a number of susceptibility genes having a minor but nonetheless significant impact on susceptibility. Migraine candidate gene studies have concentrated mainly on genes involved in neurotransmitter pathways, however evidence also exists for a role for alterations in vascular and hormonal function in migraine susceptibility. We present here a mini-review of genetic studies, investigating the potential role of vascular and hormonal gene variants, and discuss how vascular and hormonal dysfunction may impact on migraine susceptibility. We propose that the potential role of vascular and hormonal genes in this disorder warrants further investigation.
偏头痛是一种原发性头痛疾病，涉及遗传和环境因素。偏头痛被认为是一种多基因疾病，许多易感基因对易感性有微小但显著的影响。偏头痛候选基因研究主要集中在参与神经递质途径的基因上，然而，也有证据表明血管和激素功能改变在偏头痛易感性中起作用。我们在此对基因研究进行简要综述，探讨血管和激素基因变异的潜在作用，并讨论血管和激素功能障碍如何影响偏头痛易感性。我们认为血管和激素基因在这种疾病中的潜在作用值得进一步研究。
