Felde Anne B, Westermeyer Joseph, Thuras Paul
Minneapolis VAMC, MN 55417, USA.
Brain Inj. 2006 Jan;20(1):41-9. doi: 10.1080/02699050500309718.
To examine demographic factors, childhood experiences and behaviour problems and adult psychopathology associated with a history of adult traumatic brain injury (TBI) with unconsciousness in patients with substance use disorders (SUD).
Voluntary patients (n = 550) undergoing treatment for SUD were compared for clinical and demographic variables based on report of TBI.
Among the 218 (40%) patients reporting TBI, 61% were men. Childhood conduct problems and loss of a parent were strongly associated with adult TBI. Patients with TBI had more severe SUD and higher rates of depressive and anxiety symptoms, somatic concerns, physical trauma, attempted suicide and Antisocial Personality Disorder.
Men have a higher rate of TBI than women, but women with SUD have an increased relative risk of TBI compared to women in the general population. Childhood conduct problems and loss of a parent in childhood may predict adult risk-taking behaviour that leads to TBI in patients with SUD. TBI is associated with higher rates of psychopathology in patients with SUD.
研究物质使用障碍（SUD）患者中，与成年期创伤性脑损伤（TBI）伴意识丧失病史相关的人口统计学因素、童年经历、行为问题及成人精神病理学。
根据TBI报告，对550名接受SUD治疗的自愿患者的临床和人口统计学变量进行比较。
在报告有TBI的218名（40%）患者中，61%为男性。童年期行为问题和父母一方离世与成年期TBI密切相关。TBI患者的SUD更严重，抑郁和焦虑症状、躯体不适、身体创伤、自杀未遂及反社会人格障碍的发生率更高。
男性TBI发生率高于女性，但患有SUD的女性与一般人群中的女性相比，TBI的相对风险增加。童年期行为问题和父母一方离世可能预示着成年期的冒险行为，从而导致SUD患者发生TBI。TBI与SUD患者更高的精神病理学发生率相关。
