一项针对接触三氯乙烯和其他碳氢化合物的航空工作人员终末期肾病的回顾性职业队列研究。
A retrospective occupational cohort study of end-stage renal disease in aircraft workers exposed to trichloroethylene and other hydrocarbons.
作者信息
Radican Larry, Wartenberg Daniel, Rhoads George G, Schneider Dona, Wedeen Richard, Stewart Patricia, Blair Aaron
机构信息
Worldwide Outcomes Research, Merck & Co., Inc., Whitehouse Station, NJ 08889, USA.
出版信息
J Occup Environ Med. 2006 Jan;48(1):1-12. doi: 10.1097/01.jom.0000190300.51629.e0.
OBJECTIVE
Case-control studies suggest hydrocarbons increase end-stage renal disease (ESRD) risk. No cohort studies have been conducted.
METHODS
An occupational database was matched to the U.S. Renal Data System, and the outcome of all-cause ESRD was examined using multivariable Cox regression. Sixteen individual hydrocarbons were studied, although exposures were not mutually exclusive.
RESULTS
For the 1973-2000 period, there was an approximate twofold increased risk of ESRD among workers exposed to trichloroethylene, 1,1,1-trichloroethane, and JP4 gasoline compared with unexposed subjects (all P < 0.05). Relative risk was greater than unity (P > 0.05) for several other hydrocarbons. Associations attenuated (all P > 0.05) when 2001-2002 data were included in the analyses.
CONCLUSIONS
Certain hydrocarbons may increase all-cause ESRD risk. Uncertainty regarding the mechanism for increased risk and the observed attenuation in risk in 2001-2002, as well as the overlap of exposures, complicates interpretation. Additional research is needed.
目的
病例对照研究表明碳氢化合物会增加终末期肾病（ESRD）的风险。尚未进行队列研究。
方法
将一个职业数据库与美国肾脏数据系统进行匹配，并使用多变量Cox回归分析全因ESRD的结局。研究了16种单独的碳氢化合物，尽管暴露并非相互排斥。
结果
在1973 - 2000年期间，与未暴露的受试者相比，接触三氯乙烯、1,1,1 - 三氯乙烷和JP4汽油的工人患ESRD的风险大约增加了两倍（所有P < 0.05）。其他几种碳氢化合物的相对风险大于1（P > 0.05）。当将2001 - 2002年的数据纳入分析时，相关性减弱（所有P > 0.05）。
结论
某些碳氢化合物可能会增加全因ESRD的风险。风险增加的机制以及2001 - 2002年观察到的风险减弱情况存在不确定性，同时暴露的重叠也使解释变得复杂。需要进一步的研究。
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