接触三氯乙烯及其他碳氢化合物和化学品的飞机维修工人的死亡率：延长随访
Mortality of aircraft maintenance workers exposed to trichloroethylene and other hydrocarbons and chemicals: extended follow-up.
作者信息
Radican Larry, Blair Aaron, Stewart Patricia, Wartenberg Daniel
机构信息
Global Outcomes Research Department, Merck and Co, Inc, NJ 08889, USA.
出版信息
J Occup Environ Med. 2008 Nov;50(11):1306-19. doi: 10.1097/JOM.0b013e3181845f7f.
OBJECTIVE
To extend follow-up of 14,455 workers from 1990 to 2000, and evaluate mortality risk from exposure to trichloroethylene (TCE) and other chemicals.
METHODS
Multivariable Cox models were used to estimate relative risk (RR) for exposed versus unexposed workers based on previously developed exposure surrogates.
RESULTS
Among TCE-exposed workers, there was no statistically significant increased risk of all-cause mortality (RR = 1.04) or death from all cancers (RR = 1.03). Exposure-response gradients for TCE were relatively flat and did not materially change since 1990. Statistically significant excesses were found for several chemical exposure subgroups and causes and were generally consistent with the previous follow-up.
CONCLUSIONS
Patterns of mortality have not changed substantially since 1990. Although positive associations with several cancers were observed, and are consistent with the published literature, interpretation is limited due to the small numbers of events for specific exposures.
目的
对14455名工人进行从1990年至2000年的随访，并评估接触三氯乙烯（TCE）和其他化学物质的死亡风险。
方法
基于先前开发的接触替代指标，使用多变量Cox模型估计接触组与未接触组工人的相对风险（RR）。
结果
在接触TCE的工人中，全因死亡率（RR = 1.04）或所有癌症导致的死亡（RR = 1.03）没有统计学上的显著增加。自1990年以来，TCE的暴露-反应梯度相对平缓，没有实质性变化。在几个化学物质接触亚组和病因中发现了统计学上的显著超额，并且总体上与先前的随访结果一致。
结论
自1990年以来，死亡率模式没有实质性变化。虽然观察到与几种癌症存在正相关，并且与已发表的文献一致，但由于特定接触事件数量较少，解释受到限制。
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