在荷兰，与细胞学正常的女性相比，宫颈癌鳞状细胞癌中HPV16的风险更高，腺癌中HPV18的风险更高。
Preferential risk of HPV16 for squamous cell carcinoma and of HPV18 for adenocarcinoma of the cervix compared to women with normal cytology in The Netherlands.
作者信息
Bulk S, Berkhof J, Bulkmans N W J, Zielinski G D, Rozendaal L, van Kemenade F J, Snijders P J F, Meijer C J L M
机构信息
Department of Pathology, VU University Medical Center, PO Box 7057, Amsterdam 1007 MB, The Netherlands.
出版信息
Br J Cancer. 2006 Jan 16;94(1):171-5. doi: 10.1038/sj.bjc.6602915.
Abstract
We present the type-distribution of high-risk human papillomavirus (HPV) types in women with normal cytology (n=1467), adenocarcinoma in situ (ACIS) (n=61), adenocarcinoma (n=70), and squamous cell carcinoma (SCC) (n=83). Cervical adenocarcinoma and ACIS were significantly more frequently associated with HPV18 (OR(MH) 15.0; 95% CI 8.6-26.1 and 21.8; 95% CI 11.9-39.8, respectively) than normal cytology. Human papillomavirus16 was only associated with adenocarcinoma and ACIS after exclusion of HPV18-positive cases (OR(MH) 6.6; 95% CI 2.8-16.0 and 9.4; 95% CI 2.8-31.2, respectively). For SCC, HPV16 prevalence was elevated (OR(MH) 7.0; 95% CI 3.9-12.4) compared to cases with normal cytology, and HPV18 prevalence was only increased after exclusion of HPV16-positive cases (OR(MH) 4.3; 95% CI 1.6-11.6). These results suggest that HPV18 is mainly a risk factor for the development of adenocarcinoma whereas HPV16 is associated with both SCC and adenocarcinoma.
摘要
我们呈现了细胞学正常的女性（n = 1467）、原位腺癌（ACIS）（n = 61）、腺癌（n = 70）和鳞状细胞癌（SCC）（n = 83）中高危型人乳头瘤病毒（HPV）的类型分布。与细胞学正常的情况相比，宫颈腺癌和ACIS与HPV18的关联显著更频繁（OR(MH)分别为15.0；95%可信区间8.6 - 26.1和21.8；95%可信区间11.9 - 39.8）。在排除HPV18阳性病例后，人乳头瘤病毒16仅与腺癌和ACIS相关（OR(MH)分别为6.6；95%可信区间2.8 - 16.0和9.4；95%可信区间2.8 - 31.2）。对于SCC，与细胞学正常的病例相比，HPV16的患病率升高（OR(MH) 7.0；95%可信区间3.9 - 12.4），并且仅在排除HPV16阳性病例后HPV18的患病率增加（OR(MH) 4.3；95%可信区间1.6 - 11.6）。这些结果表明，HPV18主要是腺癌发生的危险因素，而HPV16与SCC和腺癌均相关。
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