Bronnikov V I, Goldyreva T P, Tereshchenko I V
Arkh Patol. 2005 Nov-Dec;67(6):18-21.
The comparison of the thyroid structure in 73 Perm sitizens who died in the 1960s with that of 59 citizens who died in the 2000s revealed in the latter group symptoms of "tissue maladaptation" (retention of follicular colloid with cystic transformation of the follicles, lymphoplasma cell infiltration with oxyfilic thyrocytes transformation into B-cells, appearance of areas with a rough connective tissue in colloidrhagia and edema with capillary collapse, calcium deposits into the vessels and stroma). It is proven that these morphological changes are due to the effects of xenobiotics. Pronounced increase of heavy metals deposits in the thyroid by the 2000s was reported. Such thyroid pathomorphosis inevitably results in hypothyroidism.
对20世纪60年代死亡的73名彼尔姆居民与21世纪死亡的59名居民的甲状腺结构进行比较，结果显示后一组出现了“组织适应不良”症状（滤泡胶体潴留伴滤泡囊性变、淋巴细胞浆细胞浸润伴嗜酸性甲状腺细胞转化为B细胞、胶体出血和水肿伴毛细血管塌陷处出现粗糙结缔组织区域、血管和基质中有钙沉积）。已证实这些形态学变化是由外源性物质的影响所致。据报道，到21世纪，甲状腺中重金属沉积物显著增加。这种甲状腺病理形态改变不可避免地导致甲状腺功能减退。
