Stepanov S A, Kalmina O A, Kalmin O V
Arkh Patol. 1996 Mar-Apr;58(2):58-62.
The material of the study was surgical thyroid biopsies from 126 patients, males and females, aged 14-69 years. 5 groups were studied depending upon the histological picture and the degree of lymphoid infiltration. Thyroids from 10 persons without thyroid pathology who died a violant life served as control. As a result of the factor analysis 5 main factors were distinguished. The first one is lymphoid infiltration, the 2nd and 3rd ones-factors of thyroid epithelium characterizing the structure and the size of thyrocytes, the 4th and the 5th factors characterize the structure of the thyroid as an organ. The analysis confirmed lymphoid infiltration and thyrocyte dimensional parameters are the most important morphological criteria in the diagnosis of thyroid pathology with immune disturbances. Six equations are derived allowing to classify new cases of thyroid pathology.
本研究的材料是126例年龄在14至69岁之间的男女患者的甲状腺手术活检样本。根据组织学图像和淋巴样浸润程度将其分为5组。选取10名死于暴力且无甲状腺病变者的甲状腺作为对照。通过因子分析鉴别出5个主要因子。第一个是淋巴样浸润，第二和第三个因子是甲状腺上皮因子，表征甲状腺细胞的结构和大小，第四和第五个因子表征甲状腺作为一个器官的结构。分析证实，淋巴样浸润和甲状腺细胞尺寸参数是诊断伴有免疫紊乱的甲状腺病变的最重要形态学标准。推导得出6个方程，可用于对甲状腺病变新病例进行分类。
