记忆激活会加重轻度认知障碍患者的脑电图异常。
Memory activation enhances EEG abnormality in mild cognitive impairment.
作者信息
van der Hiele K, Vein A A, Kramer C G S, Reijntjes R H A M, van Buchem M A, Westendorp R G J, Bollen E L E M, van Dijk J G, Middelkoop H A M
机构信息
Department of Neurology J3R, Clinical Neurophysiology and Neuropsychology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
出版信息
Neurobiol Aging. 2007 Jan;28(1):85-90. doi: 10.1016/j.neurobiolaging.2005.11.006. Epub 2006 Jan 6.
This exploratory study investigated EEG power changes during memory activation in patients with amnestic mild cognitive impairment (MCI). Twelve MCI patients and 16 age-matched controls underwent EEG registration during two conventional EEG conditions ('eyes closed' and 'eyes open') and three memory conditions ('word memory', 'picture memory' and 'animal fluency'). For all conditions, EEG power in the theta (4-8 Hz), lower alpha (8-10.5 Hz) and upper alpha (10.5-13 Hz) bands were expressed as percentile changes compared to 'eyes closed'. MCI patients showed significantly less decrease in the lower alpha band than controls (p=0.04) during picture memory activation. The word memory task showed a trend towards a similar effect (p=0.09). This study suggests that memory activation reveals EEG differences between MCI patients and controls while conventional EEG conditions do not.
这项探索性研究调查了遗忘型轻度认知障碍（MCI）患者在记忆激活过程中的脑电图（EEG）功率变化。12名MCI患者和16名年龄匹配的对照者在两种传统脑电图条件（“闭眼”和“睁眼”）以及三种记忆条件（“单词记忆”、“图片记忆”和“动物流畅性”）下进行了脑电图记录。对于所有条件，将θ波（4 - 8Hz）、低α波（8 - 10.5Hz）和高α波（10.5 - 13Hz）频段的EEG功率表示为与“闭眼”相比的百分比变化。在图片记忆激活期间，MCI患者低α波段的下降明显少于对照组（p = 0.04）。单词记忆任务显示出类似效应的趋势（p = 0.09）。这项研究表明，记忆激活揭示了MCI患者和对照组之间的脑电图差异，而传统脑电图条件下则未显示出差异。
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