Babiloni Claudio, Ferri Raffaele, Binetti Giuliano, Vecchio Fabrizio, Frisoni Giovanni B, Lanuzza Bartolo, Miniussi Carlo, Nobili Flavio, Rodriguez Guido, Rundo Francesco, Cassarino Andrea, Infarinato Francesco, Cassetta Emanuele, Salinari Serenella, Eusebi Fabrizio, Rossini Paolo M
Department of Human Physiology and Pharmacology, University La Sapienza, Rome, Italy.
Neurobiol Aging. 2009 Jan;30(1):93-102. doi: 10.1016/j.neurobiolaging.2007.05.007. Epub 2007 Jun 15.
Is directionality of electroencephalographic (EEG) synchronization abnormal in amnesic mild cognitive impairment (MCI) and Alzheimer's disease (AD)? EEG data were recorded in 64 normal elderly (Nold), 69 amnesic MCI, and 73 mild AD subjects at rest condition (closed eyes). Direction of information flux within EEG functional coupling at electrode pairs was performed by directed transfer function (DTF) at delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10 Hz), alpha 2 (10-12 Hz), beta 1 (13-20 Hz), beta 2 (20-30 Hz), and gamma (30-40 Hz). Parietal to frontal direction of the information flux within EEG functional coupling was stronger in Nold than in MCI and/or AD subjects, namely for alpha and beta rhythms. In contrast, the directional flow within inter-hemispheric EEG functional coupling did not discriminate among the three groups. These results suggest that directionality of parieto-to-frontal EEG synchronization is abnormal not only in AD but also in amnesic MCI.
遗忘型轻度认知障碍（MCI）和阿尔茨海默病（AD）患者脑电图（EEG）同步的方向性是否异常？在静息状态（闭眼）下，对64名正常老年人（Nold）、69名遗忘型MCI患者和73名轻度AD患者进行了EEG数据记录。通过在δ波（2 - 4Hz）、θ波（4 - 8Hz）、α1波（8 - 10Hz）、α2波（10 - 12Hz）、β1波（13 - 20Hz）、β2波（20 - 30Hz）和γ波（30 - 40Hz）频率下的定向传递函数（DTF）来确定电极对之间EEG功能耦合内的信息流方向。EEG功能耦合内从顶叶到额叶的信息流方向在Nold组中比在MCI组和/或AD组中更强，即对于α波和β波节律而言。相比之下，半球间EEG功能耦合内的定向流动在三组之间没有差异。这些结果表明，不仅AD患者，而且遗忘型MCI患者从顶叶到额叶的EEG同步方向性均异常。
