Mladineo Ivona, Marsic-Lucic Jasna, Buzancic Mia
Institute of Oceanography and Fisheries, P.O. Box 500, 21000 Split, Croatia.
Ecotoxicol Environ Saf. 2006 Mar;63(3):438-42. doi: 10.1016/j.ecoenv.2005.02.015.
The isopod parasite Ceratothoa oestroides becomes hard to eradicate in intensive fish rearing systems and in addition to causing weight loss in adult fish it causes mortalities in larval and juveniles stages of sea bass and sea bream. Faced with the fast emergence of this infection in Adriatic finfish facilities, an effective compound had to be tested for bath treatment. Ivermectin was chosen for this purpose on the basis of extensive practice in northern European countries which used ivermectin administered in food with good results in treatment of Lepeophtheirus sp. and Caligus sp. infections. For determination of toxicity of ivermectin, a short-term toxicity bioassay on 40-day-old sea bream, Sparus aurata, L., was conducted, following FAO and UNEP procedures for methodology in aquatic toxicity trials. Median survival time, slope functions, and 95% confidence limits for ivermectin showed moderate toxicity in sea bream, with first 100% mortalities during 96h at the concentration of 1.8 mg/L.
等足类寄生虫欧氏角头水虱在集约化养鱼系统中很难根除，它除了会导致成年鱼体重减轻外，还会导致海鲈和海鲷幼体及幼鱼阶段的死亡。面对亚得里亚海鳍鱼类养殖设施中这种感染的迅速出现，必须测试一种有效的化合物用于药浴治疗。基于北欧国家在使用添加到饲料中的伊维菌素治疗鱼虱属和锚头鳋属感染方面的广泛实践，选择了伊维菌素用于此目的。为了确定伊维菌素的毒性，按照粮农组织和环境署关于水生毒性试验方法的程序，对40日龄的金头鲷（Sparus aurata, L.）进行了短期毒性生物测定。伊维菌素的半数存活时间、斜率函数和95%置信限显示其对金头鲷有中等毒性，在浓度为1.8毫克/升时，96小时内首次出现100%死亡率。
