McGarvey L P A, Morice A H
Department of Medicine, The Queen's University of Belfast, Grosvenor Road, Belfast BT12 6BJ, N Ireland, UK.
Respir Physiol Neurobiol. 2006 Jul 28;152(3):363-71. doi: 10.1016/j.resp.2005.11.011. Epub 2006 Jan 10.
Cough is the commonest symptom of clinical importance and the most frequent reason for new consultations with a doctor. Although therapy directed at any underlying cause for cough can be effective there is a clinical need for new treatments specifically directed at the cough itself. A major obstacle to the development of such therapy has been an imprecise understanding of the pathophysiological mechanisms responsible for cough. In this article, we review the important clinical aspects of both acute and chronic cough, offer practical insight into the existing treatment options, highlight the current understanding of cough pathophysiology and identify important areas for future research effort.
咳嗽是具有临床重要性的最常见症状，也是患者新就诊的最常见原因。尽管针对咳嗽任何潜在病因的治疗可能有效，但临床上仍需要专门针对咳嗽本身的新治疗方法。开发此类治疗方法的一个主要障碍是对引起咳嗽的病理生理机制理解不精确。在本文中，我们回顾了急性和慢性咳嗽的重要临床方面，对现有治疗选择提供实用见解，强调目前对咳嗽病理生理学的理解，并确定未来研究工作的重要领域。
