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Phytochelatin synthase, papain's cousin, in stereo.

作者信息

Rea Philip A

机构信息

Plant Science Institute, Department of Biology, University of Pennsylvania, 3800 Hamilton Walk, Philadelphia, PA 19104-6018, USA.

出版信息

Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):507-8. doi: 10.1073/pnas.0509971102. Epub 2006 Jan 9.

DOI:10.1073/pnas.0509971102
PMID:16407124
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1334667/
Abstract
摘要

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本文引用的文献

1
Phytochelatins, the heavy-metal-binding peptides of plants, are synthesized from glutathione by a specific gamma-glutamylcysteine dipeptidyl transpeptidase (phytochelatin synthase).植物重金属结合肽——植物螯合肽，由特定的γ-谷氨酰半胱氨酸二肽转移酶（植物螯合肽合酶）从谷胱甘肽合成。
Proc Natl Acad Sci U S A. 1989 Sep;86(18):6838-42. doi: 10.1073/pnas.86.18.6838.
2
A papain-like enzyme at work: native and acyl-enzyme intermediate structures in phytochelatin synthesis.一种起作用的木瓜蛋白酶样酶：植物螯合肽合成中的天然和酰基酶中间体结构
Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18848-53. doi: 10.1073/pnas.0505833102. Epub 2005 Dec 9.
3
Comparative analysis of the two-step reaction catalyzed by prokaryotic and eukaryotic phytochelatin synthase by an ion-pair liquid chromatography assay.通过离子对液相色谱法对原核和真核植物螯合肽合酶催化的两步反应进行比较分析。
Planta. 2005 Sep;222(1):181-91. doi: 10.1007/s00425-005-1513-9. Epub 2005 Apr 5.
4
A cyanobacterial protein with similarity to phytochelatin synthases catalyzes the conversion of glutathione to gamma-glutamylcysteine and lacks phytochelatin synthase activity.一种与植物螯合肽合酶具有相似性的蓝细菌蛋白催化谷胱甘肽向γ-谷氨酰半胱氨酸的转化，且缺乏植物螯合肽合酶活性。
Phytochemistry. 2004 Dec;65(24):3179-85. doi: 10.1016/j.phytochem.2004.09.017.
5
Weeds, worms, and more. Papain's long-lost cousin, phytochelatin synthase.杂草、蠕虫等等。木瓜蛋白酶失散已久的近亲，植物螯合肽合酶。
Plant Physiol. 2004 Sep;136(1):2463-74. doi: 10.1104/pp.104.048579.
6
Phytochelatin synthase, a dipeptidyltransferase that undergoes multisite acylation with gamma-glutamylcysteine during catalysis: stoichiometric and site-directed mutagenic analysis of arabidopsis thaliana PCS1-catalyzed phytochelatin synthesis.植物螯合肽合酶，一种在催化过程中与γ-谷氨酰半胱氨酸发生多位点酰化的二肽基转移酶：拟南芥PCS1催化的植物螯合肽合成的化学计量和定点诱变分析
J Biol Chem. 2004 May 21;279(21):22449-60. doi: 10.1074/jbc.M313142200. Epub 2004 Mar 5.
7
Characterization of phytochelatin synthase-like protein encoded by alr0975 from a prokaryote, Nostoc sp. PCC 7120.原核生物念珠藻属Nostoc sp. PCC 7120中alr0975编码的类植物螯合肽合酶蛋白的特性分析
Biochem Biophys Res Commun. 2004 Mar 12;315(3):751-5. doi: 10.1016/j.bbrc.2004.01.122.
8
Domain organization of phytochelatin synthase: functional properties of truncated enzyme species identified by limited proteolysis.植物螯合肽合酶的结构域组织：通过有限蛋白酶解鉴定的截短酶种类的功能特性
J Biol Chem. 2004 Apr 9;279(15):14686-93. doi: 10.1074/jbc.M314325200. Epub 2004 Jan 16.
9
Phytochelatins and metallothioneins: roles in heavy metal detoxification and homeostasis.植物螯合肽和金属硫蛋白：在重金属解毒和体内平衡中的作用。
Annu Rev Plant Biol. 2002;53:159-82. doi: 10.1146/annurev.arplant.53.100301.135154.
10
Mechanism of heavy metal ion activation of phytochelatin (PC) synthase: blocked thiols are sufficient for PC synthase-catalyzed transpeptidation of glutathione and related thiol peptides.重金属离子激活植物螯合肽（PC）合酶的机制：被阻断的硫醇足以使PC合酶催化谷胱甘肽和相关硫醇肽的转肽作用。
J Biol Chem. 2000 Oct 6;275(40):31451-9. doi: 10.1074/jbc.M002997200.