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1
Weeds, worms, and more. Papain's long-lost cousin, phytochelatin synthase.杂草、蠕虫等等。木瓜蛋白酶失散已久的近亲，植物螯合肽合酶。
Plant Physiol. 2004 Sep;136(1):2463-74. doi: 10.1104/pp.104.048579.
2
Phytochelatin synthase, papain's cousin, in stereo.植物螯合肽合酶，木瓜蛋白酶的同类物，呈立体结构。
Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):507-8. doi: 10.1073/pnas.0509971102. Epub 2006 Jan 9.
3
Tolerance to toxic metals by a gene family of phytochelatin synthases from plants and yeast.植物和酵母中植物螯合肽合酶基因家族对有毒金属的耐受性
EMBO J. 1999 Jun 15;18(12):3325-33. doi: 10.1093/emboj/18.12.3325.
4
Mutagenic definition of a papain-like catalytic triad, sufficiency of the N-terminal domain for single-site core catalytic enzyme acylation, and C-terminal domain for augmentative metal activation of a eukaryotic phytochelatin synthase.木瓜蛋白酶样催化三联体的诱变定义、N 端结构域对单位点核心催化酶酰化的充分性以及 C 端结构域对真核植物螯合肽合酶增强金属激活的作用。
Plant Physiol. 2006 Jul;141(3):858-69. doi: 10.1104/pp.106.082131. Epub 2006 May 19.
5
Caenorhabditis elegans expresses a functional phytochelatin synthase.秀丽隐杆线虫表达一种功能性植物螯合肽合酶。
Eur J Biochem. 2001 Jul;268(13):3640-3. doi: 10.1046/j.1432-1327.2001.02293.x.
6
A new pathway for heavy metal detoxification in animals. Phytochelatin synthase is required for cadmium tolerance in Caenorhabditis elegans.动物体内重金属解毒的一条新途径。植物螯合肽合酶是秀丽隐杆线虫耐受镉所必需的。
J Biol Chem. 2001 Jun 15;276(24):20817-20. doi: 10.1074/jbc.C100152200. Epub 2001 Apr 19.
7
Worms take the 'phyto' out of 'phytochelatins'.蠕虫去除了植物螯合肽中的“植物”部分。
Trends Biotechnol. 2002 Feb;20(2):61-4. doi: 10.1016/s0167-7799(01)01873-x.
8
Phytochelatin synthase: of a protease a peptide polymerase made.植物螯合肽合酶：由一种蛋白酶合成的肽聚合酶。
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9
Phytochelatin biosynthesis and function in heavy-metal detoxification.植物螯合肽的生物合成及其在重金属解毒中的作用
Curr Opin Plant Biol. 2000 Jun;3(3):211-6.
10
Molecular characterization of the homo-phytochelatin synthase of soybean Glycine max: relation to phytochelatin synthase.大豆（Glycine max）同型植物螯合肽合酶的分子特征：与植物螯合肽合酶的关系
J Biol Chem. 2002 Feb 15;277(7):4747-54. doi: 10.1074/jbc.M108254200. Epub 2001 Nov 12.

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Phytochelatin Synthase: An In Silico Comparative Analysis in Cyanobacteria and Eukaryotic Microalgae.植物螯合肽合酶：蓝细菌和真核微藻的计算机模拟比较分析
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Non-Protein Thiol Compounds and Antioxidant Responses Involved in Bryophyte Heavy-Metal Tolerance.非蛋白巯基化合物与参与苔藓植物重金属耐受性的抗氧化响应。
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The Response of Thiols to Cadmium Stress in Spinach ( L.).菠菜（L.）中硫醇对镉胁迫的响应
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Ancestral function of the phytochelatin synthase C-terminal domain in inhibition of heavy metal-mediated enzyme overactivation.植物螯合肽合酶 C 端结构域在抑制重金属介导的酶过度激活中的祖先功能。
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Reconstitution of polythioamide antibiotic backbone formation reveals unusual thiotemplated assembly strategy.重建聚硫酰胺抗生素骨架形成揭示了不寻常的硫模板组装策略。
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6
Moonlighting Function of Phytochelatin Synthase1 in Extracellular Defense against Fungal Pathogens.植物螯合肽合酶 1 的兼职功能：细胞外防御真菌病原体。
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7
Evolution and functional differentiation of recently diverged phytochelatin synthase genes from Arundo donax L.芦竹中最近分化的植物螯合肽合酶基因的进化和功能分化
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8
The Sulfate Supply Maximizing Arabidopsis Shoot Growth Is Higher under Long- than Short-Term Exposure to Cadmium.与短期镉暴露相比，长期镉暴露下使拟南芥地上部生长最大化的硫酸盐供应量更高。
Front Plant Sci. 2017 May 22;8:854. doi: 10.3389/fpls.2017.00854. eCollection 2017.
9
Comparative assessment for hyperaccumulatory and phytoremediation capability of three wild weeds.三种野生杂草的超积累及植物修复能力的比较评估
3 Biotech. 2014 Dec;4(6):579-589. doi: 10.1007/s13205-014-0194-0. Epub 2014 Jan 19.
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Horizontal Gene Transfer of Phytochelatin Synthases from Bacteria to Extremophilic Green Algae.植物螯合肽合酶从细菌到嗜极绿藻的水平基因转移
Microb Ecol. 2017 Jan;73(1):50-60. doi: 10.1007/s00248-016-0848-z. Epub 2016 Sep 3.

本文引用的文献

1
Phytochelatins, the heavy-metal-binding peptides of plants, are synthesized from glutathione by a specific gamma-glutamylcysteine dipeptidyl transpeptidase (phytochelatin synthase).植物重金属结合肽——植物螯合肽，由特定的γ-谷氨酰半胱氨酸二肽转移酶（植物螯合肽合酶）从谷胱甘肽合成。
Proc Natl Acad Sci U S A. 1989 Sep;86(18):6838-42. doi: 10.1073/pnas.86.18.6838.
2
Phytochelatin synthase, a dipeptidyltransferase that undergoes multisite acylation with gamma-glutamylcysteine during catalysis: stoichiometric and site-directed mutagenic analysis of arabidopsis thaliana PCS1-catalyzed phytochelatin synthesis.植物螯合肽合酶，一种在催化过程中与γ-谷氨酰半胱氨酸发生多位点酰化的二肽基转移酶：拟南芥PCS1催化的植物螯合肽合成的化学计量和定点诱变分析
J Biol Chem. 2004 May 21;279(21):22449-60. doi: 10.1074/jbc.M313142200. Epub 2004 Mar 5.
3
Characterization of phytochelatin synthase-like protein encoded by alr0975 from a prokaryote, Nostoc sp. PCC 7120.原核生物念珠藻属Nostoc sp. PCC 7120中alr0975编码的类植物螯合肽合酶蛋白的特性分析
Biochem Biophys Res Commun. 2004 Mar 12;315(3):751-5. doi: 10.1016/j.bbrc.2004.01.122.
4
Domain organization of phytochelatin synthase: functional properties of truncated enzyme species identified by limited proteolysis.植物螯合肽合酶的结构域组织：通过有限蛋白酶解鉴定的截短酶种类的功能特性
J Biol Chem. 2004 Apr 9;279(15):14686-93. doi: 10.1074/jbc.M314325200. Epub 2004 Jan 16.
5
Localization and functional characterization of metal-binding sites in phytochelatin synthases.植物螯合肽合酶中金属结合位点的定位及功能表征
Planta. 2003 Dec;218(2):300-8. doi: 10.1007/s00425-003-1091-7. Epub 2003 Aug 5.
6
Phytochelatin synthase catalyzes key step in turnover of glutathione conjugates.植物螯合肽合酶催化谷胱甘肽共轭物周转的关键步骤。
Phytochemistry. 2003 Feb;62(3):423-31. doi: 10.1016/s0031-9422(02)00565-4.
7
Phytochelatins and metallothioneins: roles in heavy metal detoxification and homeostasis.植物螯合肽和金属硫蛋白：在重金属解毒和体内平衡中的作用。
Annu Rev Plant Biol. 2002;53:159-82. doi: 10.1146/annurev.arplant.53.100301.135154.
8
Worms take the 'phyto' out of 'phytochelatins'.蠕虫去除了植物螯合肽中的“植物”部分。
Trends Biotechnol. 2002 Feb;20(2):61-4. doi: 10.1016/s0167-7799(01)01873-x.
9
Molecular characterization of the homo-phytochelatin synthase of soybean Glycine max: relation to phytochelatin synthase.大豆（Glycine max）同型植物螯合肽合酶的分子特征：与植物螯合肽合酶的关系
J Biol Chem. 2002 Feb 15;277(7):4747-54. doi: 10.1074/jbc.M108254200. Epub 2001 Nov 12.
10
Metal-binding properties of phytochelatin-related peptides.植物螯合肽相关肽的金属结合特性。
J Inorg Biochem. 2001 Sep;86(2-3):595-602. doi: 10.1016/s0162-0134(01)00223-9.

Weeds, worms, and more. Papain's long-lost cousin, phytochelatin synthase.

作者信息

Rea Philip A, Vatamaniuk Olena K, Rigden Daniel J

机构信息

Plant Science Institute, Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

出版信息

Plant Physiol. 2004 Sep;136(1):2463-74. doi: 10.1104/pp.104.048579.

DOI:10.1104/pp.104.048579
PMID:15375203
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC523314/
Abstract
摘要