Ellis Ruth D, Fukuda Mark M, McDaniel Philip, Welch Katherine, Nisalak Ananda, Murray Clinton K, Gray Michael R, Uthaimongkol Nichapat, Buathong Nillawan, Sriwichai Sabaithip, Phasuk Rungnapha, Yingyuen Kritsanai, Mathavarat Chaiyawat, Miller Robert S
Armed Forces Research Institute for Medical Sciences (AFRIMS), Bangkok, Thailand.
Am J Trop Med Hyg. 2006 Jan;74(1):108-13.
A hospital-based study was conducted along the Thai-Myanmar border to provide greater knowledge of the causes of febrile illness and to determine what zoonotic and vector-borne emerging infectious diseases might be present. A total of 613 adults were enrolled from June 1999 to March 2002. Cases were classified based on clinical findings and laboratory results. An etiologic diagnosis was made for 48% of subjects. Malaria was the most common diagnosis, accounting for 25% of subjects, with two-thirds Plasmodium falciparum. Serologic evidence for leptospirosis was found in 17% of subjects. Other etiologic diagnoses included rickettsial infections, dengue fever, and typhoid. The most frequent clinical diagnoses were nonspecific febrile illness, respiratory infections, and gastroenteritis. Clinical associations were generally not predictive of etiologic diagnosis. Apparent dual diagnoses were common, particularly for malaria and leptospirosis. Findings have been used to modify treatment of unspecified febrile illness in the area.
在泰缅边境开展了一项基于医院的研究，以更深入了解发热性疾病的病因，并确定可能存在哪些人畜共患和媒介传播的新发传染病。1999年6月至2002年3月期间，共招募了613名成年人。病例根据临床检查结果和实验室结果进行分类。48%的受试者获得了病因诊断。疟疾是最常见的诊断，占受试者的25%，其中三分之二为恶性疟原虫。17%的受试者发现了钩端螺旋体病的血清学证据。其他病因诊断包括立克次体感染、登革热和伤寒。最常见的临床诊断是非特异性发热性疾病、呼吸道感染和肠胃炎。临床关联通常不能预测病因诊断。明显的双重诊断很常见，尤其是疟疾和钩端螺旋体病。研究结果已被用于调整该地区不明原因发热性疾病的治疗。
