Wilde Henry, Suankratay Chusana
Queen Saovabha Memorial Institute, and Division of Infectious Diseases, King Chulalongkorn University Hospital, Thai Red Cross Society, Bangkok 10330, Thailand.
J Travel Med. 2007 Jul-Aug;14(4):254-8. doi: 10.1111/j.1708-8305.2006.00094.x.
Enteric fever, typhus, leptospirosis, dengue, melioidosis, and tuberculous meningitis present urgent diagnostic problems that require experience and clinical judgment to make early evidence-based management decisions. Basic and applied research dealing with reliable antigen-based diagnostics has been published and confirmed for several of these infections. This should have initiated commercial production but has not. Established international firms see little profit in such diagnostic kits since they would be used in poor countries with little prospects for return of investment capital. We attempt to illustrate this issue, using common causes of acute febrile illnesses in the Southeast Asian region. We believe that rapid diagnostic technology could prevent significant delay in starting appropriate therapy, reduce hospital expenses, and even save lives.
伤寒、斑疹伤寒、钩端螺旋体病、登革热、类鼻疽和结核性脑膜炎带来了紧急诊断问题，需要经验和临床判断力才能做出基于证据的早期管理决策。针对其中几种感染，已发表并证实了关于可靠的基于抗原的诊断方法的基础研究和应用研究。这本应启动商业生产，但却没有。知名国际公司认为此类诊断试剂盒获利微薄，因为它们将用于投资资本回报前景渺茫的贫穷国家。我们试图以东南亚地区急性发热性疾病的常见病因来说明这一问题。我们认为，快速诊断技术可以防止在开始适当治疗方面出现重大延误，降低医院费用，甚至挽救生命。
