Kohl Peter, Bollensdorff Christian, Garny Alan
The Cardiac Mechano-Electric Feedback Group, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK.
Exp Physiol. 2006 Mar;91(2):307-21. doi: 10.1113/expphysiol.2005.031062. Epub 2006 Jan 11.
The heart is an electrically driven mechanical pump, somewhat like an electric motor. Interestingly, like an electric motor in 'dynamo mode', the heart can also convert mechanical stimuli into electrical signals. This feedback from cardiac mechanics to electrical activity involves mechanosensitive ion channels, whose properties and pathophysiological relevance are reviewed in the context of experimental and theoretical modelling of ventricular beat-by-beat electromechanical function.
心脏是一个由电驱动的机械泵，有点像电动马达。有趣的是，就像处于“发电机模式”的电动马达一样，心脏也能将机械刺激转化为电信号。这种从心脏力学反馈到电活动的过程涉及机械敏感离子通道，本文将在心室逐搏机电功能的实验和理论模型背景下，对其特性和病理生理相关性进行综述。
