Schmidt Constanze, Peyronnet Rémi
Department of Cardiology, University of Heidelberg, Heidelberg, Germany.
DZHK (German Center for Cardiovascular Research), partner site Heidelberg/Mannheim, University of Heidelberg, Heidelberg, Germany.
Herzschrittmacherther Elektrophysiol. 2018 Mar;29(1):36-42. doi: 10.1007/s00399-017-0541-z. Epub 2018 Jan 5.
Ion channels are essential for electrical signaling and contractility in cardiomyocytes. Detailed knowledge about the molecular function and regulation of cardiac ion channels is crucial for understanding cardiac physiology and pathophysiology especially in the field of arrhythmias. This review aims at providing a general overview on the identity, functional characteristics, and roles of voltage-gated as well as stretch-activated potassium selective channels in the heart. In particular, we will highlight potential therapeutic targets as well as the emerging fields of future investigations.
离子通道对于心肌细胞的电信号传导和收缩性至关重要。深入了解心脏离子通道的分子功能和调节机制对于理解心脏生理学和病理生理学，尤其是在心律失常领域，至关重要。本综述旨在对心脏中电压门控以及牵张激活的钾选择性通道的特性、功能特征和作用进行概述。特别是，我们将重点介绍潜在的治疗靶点以及未来研究的新兴领域。
