Harada Susumu, Yoshizaki Yoshitsugu, Kawasaki Yumi, Shimizu Hideki
Department of Dermatology, Sanda City Hospital.
Arerugi. 2005 Dec;54(12):1419-26.
Generally it is recognized that the occurrence of fruit allergy is attributed not to the sensitization of itself but to the cross reactivity with pollens or latex. But the relationship as to the sensitization between pollen and latex is obscure. So we aimed to investigate the relation of sensitization among pollens, fruits and latex.
We tried to examine latex-specific IgE titer and practice skin prick test of latex for the patients of pollen-food allergy syndrome.
It was confirmed that some patients of pollen-food allergy syndrome showed positive reactions against both specific IgE and skin prick test of latex, though they could tolerate latex products in their daily lives. We present here four patients of such clinical courses concretely.
The patients of pollen-food allergy syndrome should be practiced examination about latex allergy, even if they can use latex products without any symptoms. And more if positive results are obtained, additional examination such as immunoblot and IgE RAST inhibition test are recommended to practice in order to clarify the unresolved problems, such as 1) which factor is the major allergen to cause cross-reactivity among these three factors? 2) what occurs if patients of same clinical courses with our cases continue to use latex products? Further investigation will be indispensable to resolve these problems in the future.
一般认为,水果过敏的发生并非源于水果自身致敏,而是与花粉或乳胶的交叉反应有关。但花粉与乳胶之间的致敏关系尚不明确。因此,我们旨在研究花粉、水果和乳胶之间的致敏关系。
我们对花粉 - 食物过敏综合征患者进行乳胶特异性IgE滴度检测及乳胶皮肤点刺试验。
证实部分花粉 - 食物过敏综合征患者尽管在日常生活中能耐受乳胶制品,但对乳胶特异性IgE和皮肤点刺试验均呈阳性反应。我们在此具体介绍4例有此类临床过程的患者。
花粉 - 食物过敏综合征患者即使能毫无症状地使用乳胶制品,也应进行乳胶过敏检查。而且,如果结果呈阳性,建议进行免疫印迹和IgE RAST抑制试验等进一步检查,以明确一些尚未解决的问题,如:1)这三种因素中,哪种因素是导致交叉反应的主要过敏原?2)与我们病例临床过程相同的患者继续使用乳胶制品会发生什么?未来解决这些问题仍需进一步研究。