March P E
Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854.
Mol Microbiol. 1992 May;6(10):1253-7. doi: 10.1111/j.1365-2958.1992.tb00845.x.
Members of the GTPase superfamily are extremely important in regulating membrane signalling pathways in all cells. This review focuses on membrane-associated GTPases that have been described in prokaryotes. In bacteria, LepA and NodQ are very similar to protein synthesis elongation factors but apparently have membrane-related functions. The amino acid sequences of FtsY and Ffh are clearly related to eukaryotic factors involved in protein secretion. Obg and Era are not closely related to any GTPase subgroup according to amino acid sequence comparisons, but they are essential for viability. In spite of similarities to well-studied eukaryotic proteins the signalling pathways of these cellular regulators, with the exception of NodQ, have not yet been elucidated.
GTP酶超家族成员在调节所有细胞的膜信号通路中极为重要。本综述聚焦于原核生物中已被描述的膜相关GTP酶。在细菌中，LepA和NodQ与蛋白质合成延伸因子非常相似，但显然具有与膜相关的功能。FtsY和Ffh的氨基酸序列与参与蛋白质分泌的真核因子明显相关。根据氨基酸序列比较，Obg和Era与任何GTP酶亚组都没有密切关系，但它们对细胞存活至关重要。尽管这些细胞调节因子与已深入研究的真核蛋白质有相似之处，但除了NodQ之外，这些调节因子的信号通路尚未阐明。
