Bourne H R, Sanders D A, McCormick F
Department of Pharmacology, University of California, San Francisco 94143-0450.
Nature. 1991 Jan 10;349(6305):117-27. doi: 10.1038/349117a0.
GTPases are conserved molecular switches, built according to a common structural design. Rapidly accruing knowledge of individual GTPases--crystal structures, biochemical properties, or results of molecular genetic experiments--support and generate hypotheses relating structure to function in other members of the diverse family of GTPases.
