Müller M J, Acheson K J, Piolino V, Jeanpretre N, Burger A G, Jequier E
Medizinische Hochschule Hannover, Germany.
Metabolism. 1992 Jun;41(6):582-7. doi: 10.1016/0026-0495(92)90049-g.
The contribution of the basal insulin concentration to the metabolic response to epinephrine was measured in eight, postabsorptive, healthy volunteers before and during epinephrine (0.05 micrograms/kg fat-free mass [FFM] x min) and somatostatin (500 micrograms/h) infusion with and without insulin (0.1 mU/kg body weight [BW] x min) replacement. At basal plasma insulin concentrations, epinephrine increased oxygen consumption, heart rate, heart work, hepatic glucose production, glycogen breakdown in liver and muscle, and glucose oxidation, and the arterial plasma concentrations of glucose, lactate, and free fatty acids. Similar effects were observed during hypoinsulinemia, but epinephrine's actions on oxygen consumption and plasma concentrations of free fatty acids were disproportionally enhanced. We conclude that epinephrine-induced thermogenesis is partially inhibited by basal plasma insulin concentrations.
在8名处于吸收后状态的健康志愿者中，于肾上腺素（0.05微克/千克去脂体重[FFM]×分钟）和生长抑素（500微克/小时）输注期间及之前，在有和没有胰岛素（0.1毫单位/千克体重[BW]×分钟）替代的情况下，测量基础胰岛素浓度对肾上腺素代谢反应的影响。在基础血浆胰岛素浓度时，肾上腺素增加了耗氧量、心率、心脏做功、肝葡萄糖生成、肝脏和肌肉中的糖原分解以及葡萄糖氧化，以及动脉血浆中葡萄糖、乳酸和游离脂肪酸的浓度。在低胰岛素血症期间也观察到了类似的效应，但肾上腺素对耗氧量和游离脂肪酸血浆浓度的作用被不成比例地增强。我们得出结论，基础血浆胰岛素浓度可部分抑制肾上腺素诱导的产热。
