Mårin P, Darin N, Amemiya T, Andersson B, Jern S, Björntorp P
Department of Medicine I, Sahlgren's Hospital, Gothenburg, Sweden.
Metabolism. 1992 Aug;41(8):882-6. doi: 10.1016/0026-0495(92)90171-6.
Urinary cortisol output and serum cortisol concentrations were measured in the steady state, under "field" conditions, and during standardized inhibitory and stimulatory tests in premenopausal, obese women, and were analyzed in relation to adipose tissue distribution. Urinary cortisol output was increased under field conditions in women with an elevated waist to hip circumference ratio (WHR) and, in particular, in women with a large abdominal sagittal diameter, indicating visceral fat accumulation. However, dexamethasone inhibition of cortisol secretion was normal. Stimulation with corticotropin analogue and with physical (cold-pressor test) or mental (color-word or mathematic) stress tests also showed elevated responses of serum cortisol, but not of prolactin or growth hormone concentrations. It is suggested that women with visceral fat accumulation have elevated cortisol secretion due to an increased sensitivity along the hypothalamic-pituitary-adrenal axis, and that this may be causing their abnormal fat depot distribution.
在“现场”条件下，对绝经前肥胖女性在稳态时、标准化抑制和刺激试验期间的尿皮质醇排出量和血清皮质醇浓度进行了测量，并根据脂肪组织分布进行了分析。腰围与臀围比（WHR）升高的女性，尤其是矢状腹径较大的女性，在现场条件下尿皮质醇排出量增加，表明存在内脏脂肪堆积。然而，地塞米松对皮质醇分泌的抑制作用正常。促肾上腺皮质激素类似物刺激以及物理（冷加压试验）或精神（颜色词或数学）应激试验也显示血清皮质醇反应升高，但催乳素或生长激素浓度未升高。提示内脏脂肪堆积的女性由于下丘脑-垂体-肾上腺轴敏感性增加导致皮质醇分泌升高，这可能是导致其脂肪储存分布异常的原因。
