Pickwell Emma, Fitzgerald Anthony J, Cole Bryan E, Taday Philip F, Pye Richard J, Ha Thomas, Pepper Michael, Wallace Vincent P
Cambridge University, Cavendish Laboratory, Semiconductor Physics Group, Madingley Road, Cambridge CB3 0HE, United Kingdom.
J Biomed Opt. 2005 Nov-Dec;10(6):064021. doi: 10.1117/1.2137667.
Studies of basal cell carcinoma using terahertz pulsed imaging have revealed a significant difference between regions of tumor and healthy tissue. These differences are manifested in the reflected pulse due to what is thought to be changes in refractive index and absorption. We present measurements of the refractive index and absorption coefficient of excised normal tissue and basal cell carcinoma using terahertz (THz) transmission spectroscopy. We extract Debye parameters from these data and enter them into a finite difference time domain simulation to predict the shape of the waveforms reflected off the normal tissue and basal cell carcinoma and compare them with published in vivo data. Simulating the interaction of terahertz radiation with normal and cancerous tissue is a key step toward understanding the origin of contrast in terahertz images of skin cancer.
使用太赫兹脉冲成像对基底细胞癌进行的研究揭示了肿瘤区域与健康组织之间的显著差异。这些差异在反射脉冲中表现出来，这被认为是由于折射率和吸收率的变化所致。我们使用太赫兹（THz）透射光谱法对切除的正常组织和基底细胞癌的折射率和吸收系数进行了测量。我们从这些数据中提取德拜参数，并将其输入到有限差分时域模拟中，以预测从正常组织和基底细胞癌反射的波形形状，并将它们与已发表的体内数据进行比较。模拟太赫兹辐射与正常组织和癌组织的相互作用是理解皮肤癌太赫兹图像中对比度来源的关键一步。
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