Mattana Enrico, Lodi Matteo Bruno, Simone Marco, Mazzarella Giuseppe, Fanti Alessandro
Department of Electrical and Electronic EngineeringUniversity of Cagliari 09123 Cagliari Italy.
Department of ElectricalElectronics, Computer Engineering (DIEEI), University of Catania Catania Italy.
IEEE Open J Eng Med Biol. 2024 Aug 5;5:600-606. doi: 10.1109/OJEMB.2024.3438562. eCollection 2024.
THz radiationeffectively probes biological tissue water content due to its high sensibility to polar molecules. Skin and basal cell carcinoma (BCC), both rich in water, have been extensively studied in the THz range. Typically, the Double Debye model is used to study their dielectric permittivity. This work focuses on the viability of the multipole Cole-Cole model as an alternative dielectric model. To determine the best fit parameters, we used a genetic algorithm-based approach, solving a least squares problem. Compared with the Double Debye model, a maximum reduction of the RMSE value up to more than 50% and maximum relative percentage errors of 2.8% have been measured for both second and third order Cole-Cole models. Since the errors of the second and third order Cole-Cole models are similar, a two-poles model is enough to describe the behaviour both tissues from 0.2 THz to 2 THz.
太赫兹辐射由于对极性分子具有高灵敏度，能够有效地探测生物组织的含水量。皮肤和基底细胞癌（BCC）都富含水分，已在太赫兹波段得到广泛研究。通常，双德拜模型用于研究它们的介电常数。这项工作聚焦于多极科尔 - 科尔模型作为替代介电模型的可行性。为了确定最佳拟合参数，我们采用了基于遗传算法的方法，求解一个最小二乘问题。与双德拜模型相比，二阶和三阶科尔 - 科尔模型的均方根误差（RMSE）值最大降低超过50%，最大相对百分比误差为2.8%。由于二阶和三阶科尔 - 科尔模型的误差相似，一个双极模型就足以描述从0.2太赫兹到2太赫兹范围内这两种组织的行为。
