Vafapour Zohreh, Keshavarz Afsaneh, Ghahraloud Hossain
Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, 60607, USA.
Department of Electrical and Computer Engineering, University of Illinois at Chicago, Chicago, IL, USA.
Heliyon. 2020 Dec 3;6(12):e05623. doi: 10.1016/j.heliyon.2020.e05623. eCollection 2020 Dec.
The terahertz (THz) region lies between the microwave and infrared regions of the electromagnetic (EM) spectrum such that it is strongly attenuated by water and very sensitive to water content. Here, we numerically present what is to our knowledge the detecting system based on THz reflectance spectral responses data in the diagnosis of and of some cancer's samples such as skin, breast and colon cancer tissue samples. The numerical analysis on the use of semiconductor metamaterial design/device as a complex refractive index (CRI) biosensor have been carried out. We demonstrate the application of terahertz pulse detecting (TPD) in reflection geometry for the study of normal and cancerous biological tissues. THz radiation has very low photon energy and thus it does not pose any ionization hazard for biological tissues. The sensitivity of THz radiation to polar molecules, such as water, makes TPD suitable to study the diseases in human body. By studying the THz pulse shape in the time domain, we have been able to differentiate between diseased and normal tissue for the study of basal cell carcinoma (BCC), breast and colon cancers. These results demonstrate the potential of TPD for the study of skin tissue and its related disorders, both and . Findings of this study demonstrate the potential of TPD to depict breast and colon cancers and both and of skin cancer and encourage further studies to determine the sensitivity and specificity of the technique.
太赫兹（THz）波段位于电磁（EM）频谱的微波和红外波段之间，因此它会被水强烈衰减，并且对含水量非常敏感。在此，据我们所知，我们以数值方式展示了基于太赫兹反射光谱响应数据的检测系统，用于诊断某些癌症样本，如皮肤癌、乳腺癌和结肠癌组织样本。我们已经对将半导体超材料设计/器件用作复折射率（CRI）生物传感器进行了数值分析。我们展示了太赫兹脉冲检测（TPD）在反射几何结构中用于研究正常和癌变生物组织的应用。太赫兹辐射具有非常低的光子能量，因此它不会对生物组织造成任何电离危害。太赫兹辐射对极性分子（如水）的敏感性使得太赫兹脉冲检测适用于研究人体疾病。通过研究太赫兹脉冲在时域中的形状，我们能够区分病变组织和正常组织，用于研究基底细胞癌（BCC）、乳腺癌和结肠癌。这些结果证明了太赫兹脉冲检测在研究皮肤组织及其相关疾病（包括[此处原文缺失相关内容]和[此处原文缺失相关内容]）方面的潜力。本研究结果证明了太赫兹脉冲检测描绘乳腺癌和结肠癌以及皮肤癌的[此处原文缺失相关内容]和[此处原文缺失相关内容]的潜力，并鼓励进一步研究以确定该技术的敏感性和特异性。
