Axmon A, Rylander L, Albin M, Hagmar L
Division of Occupational and Environmental Medicine and Psychiatric Epidemiology, Institute of Laboratory Medicine, University Hospital, Lund, Sweden.
Hum Reprod. 2006 May;21(5):1279-84. doi: 10.1093/humrep/dei469. Epub 2006 Jan 12.
Both lifestyle factors and occupational and environmental factors have been suggested to affect the female reproductive system. In the present study, the separate and joint effects of several such factors are investigated.
Information on time to pregnancy (TTP) was available for 1578 women randomly selected from the general Swedish population. The information was collected retrospectively by using self-administered questionnaires. By means of logistic regression of survival data, fecundability odds ratios were determined for many factors. Multivariate models were used to determine which factors had the most impact on TTP.
Several lifestyle factors were found to associate with TTP. However, only use of oral contraceptives prior to attempting to conceive, menstrual cycle length, age at conception and parity remained in the multivariate models. Together, these factors explained 14% of the variance in TTP. Excluding first and second month conceptions, only age at conception and menstrual cycle length remained in the multivariate models, together explaining only 8% of the variance in TTP.
Although information on several factors was available, the multivariate model explained only a small fraction of the variation in the observed time to pregnancies. Furthermore, female biological factors seemed more important predictors of TTP than lifestyle factors.
生活方式因素以及职业和环境因素均被认为会影响女性生殖系统。在本研究中，对若干此类因素的单独及联合作用进行了调查。
从瑞典普通人群中随机选取了1578名女性，获取了她们的受孕时间（TTP）信息。这些信息通过自行填写问卷进行回顾性收集。通过对生存数据进行逻辑回归，确定了多种因素的受孕几率比。使用多变量模型来确定哪些因素对TTP影响最大。
发现若干生活方式因素与TTP相关。然而，在多变量模型中，仅保留了受孕前口服避孕药的使用情况、月经周期长度、受孕年龄和产次。这些因素共同解释了TTP方差的14%。排除第一个月和第二个月的受孕情况后，多变量模型中仅保留了受孕年龄和月经周期长度，它们共同仅解释了TTP方差的8%。
尽管掌握了若干因素的信息，但多变量模型仅解释了观察到的受孕时间变化的一小部分。此外，女性生物学因素似乎比生活方式因素更能预测TTP。
