Bretveld R, Kik S, Hooiveld M, van Rooij I, Zielhuis G, Roeleveld N
Department of Epidemiology and Biostatistics (HP 133), Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Occup Environ Med. 2008 Mar;65(3):185-90. doi: 10.1136/oem.2007.036269. Epub 2007 Sep 12.
Fertility problems are an increasing public health issue in industrialised countries. Exposure to exogenous agents with endocrine disrupting properties, such as some pesticides, are potential risk factors for subfertility. The aim of this study was to determine whether time-to-pregnancy (TTP) is prolonged in male greenhouse workers exposed to pesticides in comparison with a non-exposed reference group.
Data were collected through self-administrated questionnaires with detailed questions on TTP, as well as on lifestyle (for example, smoking habits, coffee and alcohol consumption), work tasks, and occupational exposures of the men and their partners in the six months before conception of the most recent pregnancy. TTP was compared between male greenhouse workers (n = 694) and a non-exposed reference group (n = 613) by means of discrete proportional hazards regression analysis.
The crude analyses did not show a decreased overall fecundability among greenhouse workers compared to the non-exposed reference group. However, when fecundability was assessed for primigravidous couples, duogravidous couples, and multigravidous couples separately, greenhouse workers were found to be less fecund when trying to conceive their first pregnancy (FR = 0.65; 95% CI 0.46 to 0.92), which is also the most valid analysis in which pregnancy planning issues were avoided. Among couples who already experienced one or more pregnancies, no association was seen between pesticide exposure and TTP after adjustment for confounders.
A prolonged time-to-pregnancy was observed in male greenhouse workers exposed to pesticides before conception of their first pregnancy.
在工业化国家，生育问题正成为一个日益严重的公共卫生问题。接触具有内分泌干扰特性的外源性物质，如某些农药，是导致生育力低下的潜在风险因素。本研究的目的是确定与未接触农药的对照组相比，接触农药的男性温室工人受孕时间（TTP）是否延长。
通过自行填写的问卷收集数据，问卷详细询问了受孕时间，以及生活方式（如吸烟习惯、咖啡和酒精摄入量）、工作任务，以及男性及其伴侣在最近一次怀孕前六个月的职业暴露情况。通过离散比例风险回归分析比较男性温室工人（n = 694）和未接触农药的对照组（n = 613）的受孕时间。
粗略分析未显示温室工人的总体生育力与未接触农药的对照组相比有所下降。然而，当分别评估初产妇夫妇、经产妇夫妇和多产妇夫妇的生育力时，发现温室工人在尝试首次怀孕时生育力较低（FR = 0.65；95%CI 0.46至0.92），这也是避免怀孕计划问题的最有效分析。在已经经历过一次或多次怀孕的夫妇中，调整混杂因素后，未发现农药暴露与受孕时间之间存在关联。
在首次怀孕前接触农药的男性温室工人中观察到受孕时间延长。
