Saczynski Jane S, Pfeifer Lisa A, Masaki Kamal, Korf Esther S C, Laurin Danielle, White Lon, Launer Lenore J
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, MD 20892-9205, USA.
Am J Epidemiol. 2006 Mar 1;163(5):433-40. doi: 10.1093/aje/kwj061. Epub 2006 Jan 12.
The authors examined whether low levels of social engagement in midlife and late life were associated with the risk of incident dementia in 2,513 Japanese-American men who have been followed since 1965 as part of the Honolulu Heart Program and the Honolulu-Asia Aging Study. In 1991, assessment of dementia began; incident dementia cases (n = 222) were diagnosed in 1994 and 1997. Social engagement was assessed in midlife (1968) and late life (1991). The relation between social engagement and dementia risk was examined using Cox proportional hazards models. No level of midlife social engagement was associated with the risk of dementia. In late life, compared with participants in the highest quartile of late-life social engagement, those in the lowest quartile had a significantly increased risk of dementia (hazard ratio = 2.34, 95% confidence interval: 1.18, 4.65). However, compared with those who were in the highest quartile of social engagement at both midlife and late life, only decreased social engagement from midlife to late life was associated with an increased risk of dementia (hazard ratio = 1.87, 95% confidence interval: 1.12, 3.13). Although low social engagement in late life is associated with risk of dementia, levels of late-life social engagement may already have been modified by the dementing process and may be associated with prodromal dementia.
作为檀香山心脏项目和檀香山-亚洲老龄化研究的一部分，自1965年以来，研究人员对2513名日裔美国男性进行了跟踪调查，以研究中年和晚年社交参与度较低是否与患痴呆症的风险相关。1991年开始对痴呆症进行评估；1994年和1997年诊断出222例新发痴呆症病例。分别在中年（1968年）和晚年（1991年）对社交参与度进行评估。使用Cox比例风险模型研究社交参与度与痴呆症风险之间的关系。中年社交参与度的任何水平均与痴呆症风险无关。在晚年，与晚年社交参与度最高四分位数的参与者相比，最低四分位数的参与者患痴呆症的风险显著增加（风险比=2.34，95%置信区间：1.18，4.65）。然而，与中年和晚年社交参与度均处于最高四分位数的人相比，只有从中年到晚年社交参与度下降才与痴呆症风险增加相关（风险比=1.87，95%置信区间：1.12，3.13）。虽然晚年社交参与度低与痴呆症风险相关，但晚年社交参与度水平可能已经受到痴呆症进程的影响，并且可能与前驱性痴呆症有关。
