Kaji Hiroshi, Kosaka Rieko, Yamauchi Mika, Kuno Kaoru, Chihara Kazuo, Sugimoto Toshitsugu
Division of Endocrinology/Metabolism, Neurology and Hematology/Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe.
Endocr J. 2005 Dec;52(6):659-66. doi: 10.1507/endocrj.52.659.
Peripheral quantitative computed tomography (pQCT) is useful to measure volumetric bone mineral density (vBMD) distinguishing trabecular from cortical bones as well as quantity of bone geometry. In the present study, we examined the effects of age, grip strength and smoking on vBMD, bone geometry and bone strength index (polar strength strain index (SSIp)), and then compared with the differences between female and male by employing pQCT in Japanese 252 female and 230 male subjects. Age was negatively correlated with vBMD, cortical area (Ct.Ar) and cortical thickness (Ct.Th) as well as SSIp in both sexes, and the correlation coefficients were higher in female, compared with those in male. Although age was correlated with endocortical circumferences (En.Le) in both sexes, periosteal circumferences (Ex.Le) were correlated with age only in male. Volumetric BMD, Ct.Ar, Ct.Th and SSIp were significantly lower in the group with vertebral fractures, although En.Le and Ex.Le were similar between subjects with and without vertebral fractures. Grip strength was positively correlated with vBMD, Ct.Ar, Ct.Th as well as SSIp. The extent of correlation was much higher in female, compared with that in male. Ct.vBMD, Ct.Ar, Ct.Th and SSIp, but not trabecular vBMD, were significantly lower in the group with high Brinkman index (number of cigarettes smoked per day) x (duration of smoking (years)) in female. These parameters were not significantly different between groups with high and low Brinkman index in male. In conclusion, the present study demonstrated that age, grip strength and smoking affected forearm vBMD, bone geometry and bone strength index by pQCT. These effects were greater in female, compared with those in male.
外周定量计算机断层扫描（pQCT）有助于测量体积骨密度（vBMD），区分小梁骨和皮质骨以及骨几何形态的量。在本研究中，我们通过对252名日本女性和230名日本男性受试者进行pQCT检查，研究了年龄、握力和吸烟对vBMD、骨几何形态和骨强度指数（极向强度应变指数（SSIp））的影响，然后比较了男女之间的差异。年龄与男女的vBMD、皮质面积（Ct.Ar）、皮质厚度（Ct.Th）以及SSIp均呈负相关，且女性的相关系数高于男性。虽然年龄与男女的内皮质周长（En.Le）均相关，但骨膜周长（Ex.Le）仅与男性的年龄相关。椎体骨折组的体积骨密度、Ct.Ar、Ct.Th和SSIp显著较低，尽管有或无椎体骨折的受试者之间En.Le和Ex.Le相似。握力与vBMD、Ct.Ar、Ct.Th以及SSIp呈正相关。女性的相关程度远高于男性。在女性中，高布林克曼指数（每日吸烟支数）×（吸烟持续时间（年））组的皮质vBMD、Ct.Ar、Ct.Th和SSIp显著较低，但小梁vBMD无显著差异。在男性中，高、低布林克曼指数组之间这些参数无显著差异。总之，本研究表明，年龄、握力和吸烟通过pQCT影响前臂vBMD、骨几何形态和骨强度指数。这些影响在女性中比在男性中更大。
