Sai H, Iguchi G, Tobimatsu T, Takahashi K, Otani T, Horii K, Mano I, Nagai I, Iio H, Fujita T, Yoh K, Baba H
Department of Biosignal Pathophysiology, Kobe University Graduate School of Medicine, Kobe, Japan.
Osteoporos Int. 2010 Oct;21(10):1781-90. doi: 10.1007/s00198-010-1217-2. Epub 2010 Jun 1.
A reference database for trabecular bone density, cortical thickness, and elastic modulus of trabecular bone for a novel ultrasonic bone densitometry system (LD-100) based on two longitudinal waves (fast and slow) was determined over a wide age range in a normal Japanese population.
A novel ultrasonic bone densitometry system (LD-100 system) was applied to create a reference database for trabecular bone density (TBD), cortical thickness (CoTh), and elastic modulus of trabecular bone (EMTb) for this device over a wide age range in a normal Japanese population.
In a comparative study between LD-100 and peripheral quantitative computed tomography (pQCT) systems, 52 individuals were examined by both systems at the same radius simultaneously. To create a reference database, a total of 2,380 healthy subjects (1,179 men, 1,201 women), ages 18-99 years, were examined using the LD-100 system.
Highly significant correlations between the LD-100 and pQCT systems were found in TBD (r = 0.877, p < 0.001) and CoTh (r = 0.723, p < 0.001). For the reference database, peak values of TBD, CoTh, and EMTb were observed at 30-34 years (255.09 mg/cm(3)), 20-24 years (5.23 mm), and 20-24 years (4.09 GPa) in men, and at 25-29 years (209.24 mg/cm(3)), 25-29 years (3.98 mm), and 20-24 years (3.33 GPa) in women, respectively. The TBD fell significantly (p < 0.05) beginning at 55-59 years in both sexes, with a relatively rapid decrease in women. The CoTh showed a significant decrease beginning at 40-44 years in men and 50-54 years in women. The EMTb showed a significant decrease beginning at 40-44 years in men and 55-59 years in women.
The LD-100 system is a useful bone densitometry device and the database of age-related changes in TBD, CoTh, and EMTb established in this study will provide fundamental data for future studies related to bone status.
基于两种纵波（快波和慢波）的新型超声骨密度测定系统（LD - 100），在正常日本人群的广泛年龄范围内，确定了小梁骨密度、皮质厚度和小梁骨弹性模量的参考数据库。
应用一种新型超声骨密度测定系统（LD - 100系统），在正常日本人群的广泛年龄范围内，为该设备创建小梁骨密度（TBD）、皮质厚度（CoTh）和小梁骨弹性模量（EMTb）的参考数据库。
在LD - 100和外周定量计算机断层扫描（pQCT）系统的对比研究中，52名个体在同一半径处同时接受两种系统的检查。为创建参考数据库，使用LD - 100系统对总共2380名年龄在18 - 99岁的健康受试者（1179名男性，1201名女性）进行了检查。
在TBD（r = 0.877，p < 0.001）和CoTh（r = 0.723，p < 0.001）方面，LD - 100和pQCT系统之间发现高度显著的相关性。对于参考数据库，男性的TBD、CoTh和EMTb峰值分别在30 - 34岁（255.09mg/cm³）、20 - 24岁（5.23mm）和20 - 24岁（4.09GPa）时观察到，女性分别在25 - 29岁（209.24mg/cm³）、25 - 29岁（3.98mm）和20 - 24岁（3.33GPa）时观察到。两性在55 - 59岁开始TBD显著下降（p < 0.05），女性下降相对较快。男性在40 - 44岁开始CoTh显著下降，女性在50 - 54岁开始显著下降。男性在40 - 44岁开始EMTb显著下降，女性在55 - 59岁开始显著下降。
LD - 100系统是一种有用的骨密度测定设备，本研究建立的TBD、CoTh和EMTb与年龄相关变化的数据库将为未来与骨状态相关的研究提供基础数据。
