Hasegawa Y, Schneider P, Reiners C
Clinic for Nuclear Medicine, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
J Biomech. 2001 Apr;34(4):497-503. doi: 10.1016/s0021-9290(00)00211-6.
The purpose of this study was to estimate the relation of some noninvasively derived mechanical characteristics of radial bone including architectural parameters for bone strength to grip strength and muscle cross-section. Sixty-three males between 21 and 78yr of age and 101 females between 18 and 80yr of age were measured at the nondominant forearm using peripheral quantitative computed tomography (pQCT). We assessed the integral bone mineral density (BMD(I)) and content (BMC(I)) by pQCT at the distal and at the mid-shaft radius. Integral bone area (Area(I)), cortical thickness (C-th), and a newly proposed index for bone strength; the stress-strain index (SSI) were also calculated. The dynamometrically measured maximum grip strength was taken as a mechanical loading parameter and muscle cross-section as a substitute for it. Sex, grip strength, BMC(I) and BMD(I) (distal radius) were identified in a multiple regression analysis to significantly predict bone strength as expressed by SSI, after adjusting for all other independent variables, including age and sex (p<0.0001). Grip strength was closest related to age, sex, BMD(I) and SSI(p) of the distal radius. The cross-sectional area of muscle was not significantly determining the grip strength within the analysis model. In conclusion, our results suggested that architectural parameters at the distal radius were better related to grip strength than to cross-sectional muscle area in both males and females. Maximum muscle strength as estimated by grip strength might be a stronger determinant of mechanical characteristics of bones as compared with cross-sectional muscle area.
本研究的目的是评估桡骨一些非侵入性得出的力学特性（包括骨强度的结构参数）与握力和肌肉横截面积之间的关系。使用外周定量计算机断层扫描（pQCT）对63名年龄在21至78岁之间的男性和101名年龄在18至80岁之间的女性的非优势前臂进行了测量。我们通过pQCT评估了桡骨远端和骨干中部的整体骨密度（BMD(I)）和骨量（BMC(I)）。还计算了整体骨面积（Area(I)）、皮质厚度（C-th）以及一个新提出的骨强度指标——应力应变指数（SSI）。将测力计测量的最大握力作为机械负荷参数，并以肌肉横截面积作为其替代指标。在多元回归分析中，在对包括年龄和性别在内的所有其他自变量进行调整后，确定性别、握力、BMC(I)和BMD(I)（桡骨远端）可显著预测由SSI表示的骨强度（p<0.0001）。握力与年龄、性别、桡骨远端的BMD(I)和SSI(p)最相关。在分析模型中，肌肉横截面积对握力的影响不显著。总之，我们的结果表明，桡骨远端的结构参数与握力的相关性优于与肌肉横截面积的相关性，在男性和女性中均如此。与肌肉横截面积相比，由握力估计的最大肌肉力量可能是骨骼力学特性的更强决定因素。
