Winocur Gordon, Wojtowicz J Martin, Sekeres Melanie, Snyder Jason S, Wang Sabrina
Department of Psychology, Trent University, Peterborough, Ontario.
Hippocampus. 2006;16(3):296-304. doi: 10.1002/hipo.20163.
Rats treated with low dose irradiation, to inhibit adult hippocampal neurogenesis, and control rats were administered a non-matching-to-sample (NMTS) task, which measured conditional rule learning and memory for specific events, and a test of fear conditioning in which a discrete CS was paired with an aversive US in a complex environment. Irradiated rats were impaired on the NMTS task when the intervals between sample and test trials were relatively long, and in associating the shock-induced fear with contextual cues in the fear conditioning task. Irradiated rats were not impaired in learning the basic NMTS rule or in performing that task when the intervals between the sample and test trials were short. Nor were there group differences in conditioning the fear response to the CS in the fear conditioning task. The results, which extend the range of hippocampus-dependent tasks that can be said to be vulnerable to the effects of neurogenesis suppression, support the hypothesis that new hippocampal cells generated in adulthood participate in a broad range of hippocampal functions.
用低剂量辐射处理大鼠以抑制成年海马神经发生，对处理后的大鼠和对照大鼠进行了一项非匹配样本（NMTS）任务，该任务测量特定事件的条件规则学习和记忆，以及一项恐惧条件测试，在复杂环境中将离散的条件刺激（CS）与厌恶的非条件刺激（US）配对。当样本试验和测试试验之间的间隔相对较长时，接受辐射的大鼠在NMTS任务上表现受损，并且在恐惧条件任务中将电击诱发的恐惧与情境线索相关联时也表现受损。当样本试验和测试试验之间的间隔较短时，接受辐射的大鼠在学习基本的NMTS规则或执行该任务方面没有受损。在恐惧条件任务中，对CS的恐惧反应条件化方面也没有组间差异。这些结果扩展了可被认为易受神经发生抑制影响的依赖海马体任务的范围，支持了成年期产生的新海马细胞参与广泛海马功能的假说。
