Saeed Sadia, Ahmad Samia, Rasool Sheikh Ajaz
Department of Microbiology, University of Karachi, Karachi-75270.
Pak J Pharm Sci. 2004 Jan;17(1):1-8.
Staphylococcus aureus 188 has been shown to produce bacteriocin-like inhibitory substance known as staphylococcin 188. It has a broad-activity spectrum against Micrococcus luteus, Streptococcus pneumoniae, Streptococcus faecalis, Streptococcus viridans, Corynebacterium diphtheriae and several staphylococcus species. The arbitrary unit of staphylococcin 188 against Micrococcus luteus was 1280 AU/mL. Its production with simultaneous measurement of activity was monitored and was found to produce maximum amount of staphylococcin after 7 hours of incubation. Mode of action of the staphylococcin 188 on the sensitive cells was bactericidal rather than bacterioloytic.
金黄色葡萄球菌188已被证明能产生一种名为葡萄球菌素188的类细菌素抑制物质。它对藤黄微球菌、肺炎链球菌、粪肠球菌、草绿色链球菌、白喉棒状杆菌和几种葡萄球菌具有广泛的活性谱。葡萄球菌素188对藤黄微球菌的任意单位为1280 AU/mL。监测其产生过程并同时测量活性，发现培养7小时后产生的葡萄球菌素量最大。葡萄球菌素188对敏感细胞的作用方式是杀菌而非溶菌。
